Project Grant R21AI191036

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $410K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This Project Grant award of $285,816 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research to enhance understanding of ADP-ribosylation (ADPR) and its role in HIV-1 latency and reactivation. The awardee, The Regents of the University of California, San Francisco, will conduct biochemical, proteomic, and cellular assays to identify global proteomic changes to ADPR during HIV-1 latency and reactivation,...
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $197,646 to the University of California, San Diego (UC San Diego) to conduct research on enhancing bacteriophage function with coevolution and synthetic biology. The overall objective is to use experimental evolution to identify genetic changes in phages that enhance their ability to suppress bacterial growth,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $481,250 to The Broad Institute, Inc. to develop antimicrobial compounds that recruit the immune system to target bacteria. The project will involve biochemical, biophysical, and cell biology experiments to characterize chimeric molecules that combine bacterial binders and immune system protein binders. This research aims to create...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $125,619 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Santa Cruz (UCSC) to investigate how the bacterial pathogen Helicobacter pylori utilizes ribosomal silencing to maintain chronic gastric infections. The research aims to expand understanding of how H. pylori regulates its ribosome population under growth-limiting conditions, such as biofilms,...
This $531,245 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research by Yale University to structurally and functionally characterize the sorting platform component of the type III secretion system (T3SS) in Salmonella bacteria. Through a multidisciplinary approach involving bacterial genetics, biochemistry, microscopy, and cryo-electron microscopy, the research aims to...
This federal Project Grant award of $643,718 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how interferon-regulatory factors (IRFs) and STAT transcription factors remodel the epigenome and chromosome organization of macrophages to reprogram their immune responses. The research aims to: 1) dissect the roles of innate immune IRFs in de novo enhancer formation, 2)...
This federal Project Grant award of $696,544 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of California, Davis to uncover the contractile attachment mechanisms of the ventral disc in the intestinal parasite Giardia lamblia. The research aims to leverage new CRISPR-based genetic tools, live imaging, and biophysical assays to evaluate how specific structural...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $222,852 to support research into the regulation of virulence factors in the pathogenic bacterium Clostridioides difficile. The primary objective is to identify and annotate Rho, NusA, and NusG dependent transcriptional terminators in C. difficile to understand how these regulatory factors influence the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
The federal Project Grant award F31AI181575, totaling $125,160.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). This grant supports research by The Ohio State University to characterize a novel bacterial immune system with unknown mechanisms. The research aims to use cryogenic electron microscopy and biochemical/cellular assays to define the structure, assembly, and functions of a...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $410,497 to the University of California, Santa Barbara to conduct research on a novel effector delivery mechanism used by Bordetella bacteria to translocate toxic effector domains directly into host cells. The project aims to determine if the bacterial adhesin protein FHAL functions as a contact-dependent effector delivery system, and to test whether the FHAL effector domains act as toxic hydrolases to disrupt host cell physiology. The award period runs from Jul 1, 2025 to Jun 30, 2027.

Generated 8/5/25, 5:30 AM