Project Grant R21AI190763
- Federal Grant Award Summary Mayo Clinic Arizona received a $197,600 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective November 1, 2025, through April 30, 2027. The research project focuses on assessing food-specific tolerogenic CD4+ T cells and their role in protection from food allergy. The grant supports investigation into the immunological mechanisms by which oral...
- Federal Grant Award Summary Mayo Clinic received a $441,098 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 23, 2025, with a completion date of June 30, 2027. The research project, conducted at Mayo Clinic's Minnesota facility, investigates the antagonistic actions of IRF4 (Interferon Regulatory Factor 4) and BACH2 (BTB Domain and CNC Homolog 2) transcription...
- Federal Project Grant Award Summary Mayo Clinic Arizona, a nonprofit academic medical center and research institution, received a $486,109 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, effective July 1, 2025, through June 30, 2027, supports investigator-initiated biomedical research examining Type 2 immune responses in endotoxemia-induced lung injury. The research project...
- Federal Project Grant Award Summary Mayo Clinic has received a $624,521 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 24, 2026, with a completion date of January 31, 2031. The grant supports fundamental research investigating the regulation of target cell survival by the protein kinases TBK1 (TANK-Binding Kinase 1) and IKKε (Inducible IκB Kinase Epsilon), utilizing...
- Federal Grant Award Summary Mayo Clinic Arizona has been awarded $156,080 by the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) to conduct research on the functional role of KLRG1+ conventional helper T cells in the tumor microenvironment. The project, which commenced on December 25, 2025, and will conclude on July 31, 2028, aims to define how killer cell lectin-like receptor G1 (KLRG1) expressing CD4+ T cells contribute to cancer progression and immune...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Arizona a Project Grant totaling $155,479 on June 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for development of immune evasive transgenic mouse models to support transplantation research. The two-year project, concluding May 31, 2028, will generate specialized mouse models designed to overcome immunological barriers to organ and...
- Federal Project Grant Award Summary Award Details: Emory University received a $100,228 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award was obligated on September 30, 2026, with an ultimate completion date of March 31, 2029, and performance will be conducted at Emory University's Atlanta, Georgia campus. Research Scope: This project grant funds biomedical research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a $445,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct investigator-initiated biomedical research on immunoregulatory mechanisms controlling myeloid trained immunity following organ transplantation. The award, obligated on February 18, 2026, with a completion date of January 31, 2031, supports a five-year...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Minnesota a $423,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period July 1, 2025, through June 30, 2027. The award funds a two-year research project investigating the immunobiological mechanisms underlying immune tolerance to transplanted pancreatic islets in nonhuman primates. The research addresses a...
- Federal Grant Award Summary Arizona State University received a $742,634 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on May 13, 2026, with a completion date of April 30, 2031. The award supports research into placental mimicry cell therapy mechanisms to advance stem cell-derived insulin-secreting beta cell (SBC) therapies for Type 1 diabetes treatment. The project aims to...
Mayo Clinic Arizona received a $209,765 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 20, 2026, through April 30, 2028. The award supports research on TIGIT+ B cell therapy as a novel immunotherapeutic strategy to promote transplantation tolerance and reduce the need for long-term immunosuppression in transplant recipients. The research involves validation of the immune regulatory functions of TIGIT+ B cells generated through a replication-incompetent adenovirus vector (ADV5.K7.TIGIT), with the goal of demonstrating the cells' capacity to suppress acute graft-versus-host disease while preserving host immunity. The project addresses a critical clinical need by developing an alternative to conventional immunosuppressive regimens, which carry significant risks of infection, malignancy, and adverse side effects in transplant patients. Through this two-aim research initiative conducted at the Mayo Clinic Arizona facility in Scottsdale, the study will generate scientific evidence regarding the therapeutic potential of TIGIT+ B cells, with anticipated outcomes that could advance clinical options for improving long-term transplant outcomes and patient quality of life.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $209.8k | 5/22/26 |