Project Grant R21AI190747
Award Date
2/24/25
Completion Date
1/31/27
Dollars Obligated
$250K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Iowa City, IA 52242, USA
Similar Awards
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $368,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Texas Health Science Center at San Antonio (UTHSCSA). The grant supports a 2-year research project to investigate the role of translational mechanisms in controlling conidial germination, a critical virulence process, in the human fungal pathogen Aspergillus fumigatus. The project aims to determine the...
The University of Iowa was awarded a Project Grant of $443,175 by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to develop a high-throughput screening assay to identify novel antifungal compounds active against the mold Aspergillus fumigatus. This grant aims to address the high mortality rates and increasing resistance to current antifungal treatments for invasive mold infections, which primarily impact immunocompromised...
This federal Project Grant award of $1,042,754 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program) supports research to define the mechanisms by which the calcineurin enzyme regulates antifungal response and resistance in the Aspergillus fumigatus fungus. The project aims to identify key calcineurin effectors that govern cell wall and membrane integrity, and elucidate calcineurin's transcriptional and post-translational...
The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. Department of Health and Human Services, has awarded a $300,156 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Intact Genomics Inc., a minority-owned small business. The funding will support research to identify new antifungal compounds with novel mechanisms of action from filamentous fungi. The key objectives are to demonstrate the use of Aspergillus nidulans as a...
This $181,861 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support the development of novel, rapid, and noninvasive diagnostic and prognostic biomarkers for invasive aspergillosis (IA) based on host transcriptional responses. The key objectives are:
Deriving and optimizing a diagnostic host gene expression signature of IA from a large established repository.
Enrolling and serially sampling...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $642,775 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Davis to accelerate the discovery of new antifungal peptides using one-bead one-compound (OBOC) combinatorial technology. The research aims to rapidly develop and optimize novel broad-spectrum antifungal agents with defined physicochemical properties, diverse mechanisms of action, and a high...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Microrid Technologies Inc. located in Dix Hills, NY. The goal of this 1-year project is to discover and develop new antifungal therapeutics that target the fungal enzyme ceramide synthase 1 (CER1), which is essential for fungal growth and survival in host environments. The researchers will screen compound libraries to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to define the mechanisms by which the protein kinase A (PKA) regulates autophagy pathways in the fungal pathogen Aspergillus fumigatus. The funding of $477,103 will be used to: 1) validate PKA-dependent phosphorylation and regulation of prioritized autophagy-associated proteins in A. fumigatus, and 2) characterize the roles...
This federal Project Grant award of $750,815, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research), supports research to develop novel anti-infective strategies for treating pulmonary mucormycosis, a deadly invasive fungal infection.
The project aims to examine the role of the host cell hypoxia-response pathway in mucormycosis pathogenesis and explore the therapeutic potential of targeting key downstream effectors like...
This $435,577 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to elucidate the molecular mechanisms by which the septin cytoskeleton in the human pathogen Aspergillus fumigatus mediates the fungistatic response to the antifungal drug caspofungin. The 5-year project, conducted by Virginia Polytechnic Institute & State University, will 1) determine the role of the septin cytoskeleton in...