Project Grant R21AI190655
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a $392,634 Project Grant effective May 13, 2025, through April 30, 2030, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds the development of a novel nanoimmunotherapeutic treatment approach targeting multidrug-resistant (MDR) bacterial infections, specifically gram-negative ESKAPE pathogens including...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin-Madison a Project Grant totaling $427,625 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 1, 2025, through July 31, 2027. This grant funds research to develop innovative probiotic-based therapeutic delivery systems using the gut symbiont Limosilactobacillus reuteri for recombinant protein production in humans. The...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $560,178 Project Grant to the University of Wisconsin-Madison on July 25, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant funds a five-year research project (completion date June 30, 2030) investigating the role of FSA3 prophages as molecular regulatory switches controlling beta-toxin production in Staphylococcus aureus. The research aims to...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin-Madison a Project Grant totaling $243,750 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 10, 2025, with a completion date of June 30, 2027. The grant funds research investigating the mechanisms by which Gardnerella species promote Neisseria gonorrhoeae pathogenesis, particularly in women with bacterial vaginosis (BV). The research...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $241,500 Project Grant to the University of California, Davis on August 21, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct biomedical research on Clostridioides difficile infection prevention. The research will be performed at UC Davis's Davis, California campus through July 31, 2027. The project focuses on understanding how colonization...
- Summary of Federal Project Grant Award The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded $161,859 to Texas A&M University System Health Science Center (effective August 11, 2025, through July 31, 2027) to conduct research focused on discovering novel antivirulence drug targets for Clostridioides difficile infection (CDI). The project addresses the critical clinical need for microbiome-sparing...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a $692,689 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 10, 2025, with a completion date of June 30, 2030. This award supports investigator-initiated biomedical research focused on understanding the determinants of pegivirus persistence and immune control mechanisms. The research leverages a...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Maryland, Baltimore a $1,230,575 Project Grant on March 10, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a novel probiotic yeast-based oral immunotherapy against Clostridioides difficile transmission. The primary deliverable is the development and validation of engineered probiotic yeast strains that express bi-specific variable...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin-Madison a $427,625 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 1, 2026, with a completion date of January 31, 2028. The grant funds research investigating the mechanisms of fallopian tube damage caused by Neisseria gonorrhoeae infection that results in pelvic inflammatory disease. The research will utilize human...
- Grant Award Summary Tufts University School of Medicine received a Project Grant award of $136,104 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective October 24, 2025, with an ultimate completion date of May 31, 2028. The research focuses on investigating how Clostridioides difficile bacterial localization and toxin gene expression affect disease severity in murine infection models. The...
Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin System a $434,684 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period February 1, 2026 through January 31, 2028. This research project investigates the impacts of glutathione (GSH) on Clostridioides difficile infection (CDI), with the ultimate goal of developing novel therapeutic strategies to reduce C. difficile fitness and pathogenesis in the gastrointestinal tract. The research addresses critical gaps in understanding how C. difficile, a cysteine auxotroph bacterium, acquires essential amino acids during infection and examines the role of GSH—the most abundant low molecular weight thiol in mammalian cells—as a potential cysteine source for the pathogen. The project will generate research outputs focused on elucidating the C. difficile-, microbiome-, and host-based determinants of GSH levels in the gastrointestinal tract under normal conditions and during active CDI. By advancing understanding of these metabolic processes, the research is intended to support the development of more precise treatment strategies that move beyond current antibiotic-based approaches and microbiome restoration therapies, thereby reducing the incidence of antibiotic resistance and recurrent CDI. The work will be conducted at the University of Wisconsin-Madison campus located in Madison, Wisconsin.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $434.7k | 1/30/26 |