Project Grant R01AI192811

Award Date 7/10/25
Completion Date 6/30/30
Dollars Obligated $693K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This federal Project Grant award of $692,689 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to advance understanding of pegivirus persistence and immune control. The primary research objectives are to:

  1. Determine the adaptive immune functions responsible for "semi-control" of mouse-adapted pegivirus (MAPGV) infection in wild-type mice. This will involve using immune gene-knockout mice and lymphocyte depletion studies to identify the specific lymphocyte subsets and effector functions mediating this partial viral control.

  2. Determine the adaptive immune functions responsible for "elite control" of MAPGV infection, where a subset of wild-type mice can completely clear the virus. Passive transfer experiments and purified lymphocyte subset transfers will be used to attribute elite control to specific immune cell populations.

  3. Develop tools to quantify anti-MAPGV immune responses in both semi-controllers and elite controllers, providing insights into the immune mechanisms governing pegivirus persistence and clearance.

The award was granted to the University of Wisconsin System, which has a strong track record of federal research funding across multiple scientific domains. The project aims to advance fundamental understanding of pegivirus biology and immune responses, with potential broader implications for chronic viral infections.

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