This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $147,486 to The Medical College of Wisconsin, Inc. to conduct research aimed at uncovering the proviral role of B cell-intrinsic STAT1 expression during chronic gammaherpesvirus infection. The research project leverages the murine gammaherpesvirus 68 (MHV68) model to investigate how this virus usurps B cell-intrinsic STAT1 expression to...
This $775,391 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to investigate the role of the human protein galectin-9 in HIV persistence and the establishment of the long-term viral reservoir. The primary awardee, Vitalant Research Institute, will conduct in vitro studies to elucidate the molecular and immunological mechanisms underlying galectin-9's impact on the HIV reservoir. Additionally,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,085,097.00 to the University of Wisconsin - Madison to study the role of cryptic influenza virus proteins in viral replication and pathogenesis. The research aims to characterize the interference activity and mechanism of action of these previously unknown viral proteins, define the full repertoire of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $147,486.00 to the Icahn School of Medicine at Mount Sinai to conduct high-resolution immunological characterizations of a novel murine model of chronic hepacivirus infection. The goal is to study the evolution of immune dysfunction over the course of infection and better understand the molecular drivers of T cell exhaustion and viral...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $598,764 to The Trustees of Princeton University to conduct research aimed at disrupting the formation of HBV cccDNA to combat chronic HBV infection, particularly in the context of HIV co-infection. The key objectives are to: 1) determine whether genetic disruption of host factors involved in HBV cccDNA...
This $510,306 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to advance the understanding of virus-host interactions for developing a cure against chronic hepatitis B virus (HBV) infections. The primary goal is to investigate the mechanisms by which interferon-alpha treatment can lead to a functional cure for HBV, as well as explore the impact of HBV...
This federal Project Grant award of $429,000.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine chromatin architecture and gene regulatory networks in Anopheles coluzzii mosquito hemocyte cells. The key objectives are to 1) map chromatin architecture during immune activation in mosquito hemocyte cells, and 2) identify gene regulatory networks for the immune...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
This $847,428 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to understand the mechanisms of hepatitis B virus (HBV) persistence and clearance in chronic hepatitis B patients, with a focus on evaluating intrahepatic cccDNA and integrated DNA. The primary awardee, Beth Israel Deaconess Medical Center, will conduct translational research to quantify cccDNA and integrated DNA levels,...
This $427,627 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate how gamma herpesvirus infection impacts key pathogenic interactions between B cells and CD4 T cells in a mouse model of multiple sclerosis (MS). The research aims to determine how viral infection affects B cells' support of disease-driving CD4 T cells, and how this impacts B cell-dependent versus B...