This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will provide $256,995.00 to Tufts University School of Medicine to conduct research on intracellular bacterial pathogens, such as Legionella pneumophila. The goal is to develop a new quantitative method using optical sequencing to identify host cell mutations that impact key bacterial traits, such as iron starvation and fitness. This...
This $1,361,909 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to identify and characterize genes required for the cytosolic survival of the bacterial pathogen Listeria monocytogenes. The project aims to understand how this intracellular pathogen has adapted to thrive in the host cell cytosol, a challenging environment. Specifically, the research focuses on elucidating the roles of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $159,362.00 to the University of Illinois to evaluate the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence. The key objectives are to: 1) Determine how the lipoic acid transfer enzyme LipL interfaces with the enzyme PTA to control energy balance during S. aureus overflow metabolism, and 2)...
This federal Project Grant award of $1,444,195.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to discover strategies for enhancing the activity of existing and new topoisomerase inhibitor antibiotics against persistent and resistant Escherichia coli and Pseudomonas aeruginosa bacterial infections. The research aims to identify metabolites that can modulate bacterial...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,379,734 to the University of Texas at Austin to conduct research on the use of microcin antibacterial proteins to overcome the permeability barrier of Gram-negative bacteria. The research aims to identify new approaches to antibiotic development that can enter and kill multidrug-resistant pathogens. The project will investigate the...
This $506,394 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the molecular and cellular mechanisms by which bacterial cholesterol-dependent cytolysins (CDCs) activate the NLRP3 inflammasome signaling pathway. The research aims to characterize the abilities of different types of CDCs to reorganize host organelles and stimulate or evade the...
This $1,837,312.93 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant will fund research at the University of Texas Health Science Center at San Antonio (UTHSCSA) to investigate the enzyme SAMHD1 and how its allosteric and post-translational regulation enable distinct states of cellular dNTP metabolism, which in turn impacts susceptibility to HIV...
This federal Project Grant award in the amount of $631,977.00, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on November 18, 2024, supports research to enhance immunological memory and pathogen control through nutritional interventions.
The key objectives are to: (I) reveal how caloric restriction can be utilized to enhance pathogen- and vaccine-elicited immunological memory, and (II) develop novel therapies that...
This $502,861 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the role of the protein PCIF1 in regulating host-HIV interactions. The key objectives are to: 1) Define the dynamics and mapping of human N6,2'-O-dimethyladenosine (m6Am) RNA methylome in response to HIV infection and methamphetamine exposure; 2) Determine how HIV alters the m6Am methylome of host cells; and 3)...
This federal Project Grant award, totaling $877,802, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is funding research at the University of Tennessee Health Science Center to elucidate the molecular mechanisms by which the cell surface receptor Siglec-E regulates the immune response to bacterial infections, with a focus on differential responses to gram-positive and...