This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is focused on elucidating the complex interplay between human rotaviruses (RVs) and extracellular vesicles (EVs) in the context of virus egress, protection, and infection. The $481,250 award, with a project period from Jul 16, 2025 to Jun 30, 2027, will enable researchers at Vanderbilt University Medical Center to use cell culture models (Caco-2, HT29, H69, and human intestinal enteroids) to investigate how RV association with EVs, including through external adhesion, differentially influences virus egress, shielding, and infection properties in a donor cell-specific manner. The goal is to enhance the understanding of fundamental human RV biology and inform the selection of appropriate culture models for studying RV egress and infection.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $481.3k | 7/16/25 |