This federal Project Grant award of $883,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop a thermostable measles fusion (F) glycoprotein vaccine strategy. The key objectives are to engineer a thermostable measles F protein immunogen and evaluate the protective immune responses it elicits, with the goal of creating a vaccine that is safe and effective for...
This $303,076 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to determine the molecular, cellular, and evolutionary mechanisms by which viral pathogens evade or co-opt host innate immune defensin peptides to enhance infectivity. The studies will use a library of chimeric defensin peptides to investigate the structural and biochemical properties...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), focuses on studying the factors that influence the efficiency of influenza A virus (IAV) infection in a recipient host. The $146,922 award will support research to investigate how the mode of viral exposure (direct contact, self-inoculation, or airborne transmission) and environmental conditions, such as temperature and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $188,544 to The University of Iowa to study the role of the protein SAMHD1 in regulating the immune response to SARS-CoV-2 infection. The research aims to better understand how SARS-CoV-2 infection affects SAMHD1 phosphorylation and how this impacts viral replication, inflammation, and antiviral immunity in lung and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $805,375 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS). The goal of this research project is to elucidate critical unknowns about the cellular tropism, receptor usage, and pathogenesis mechanisms of Pararubulaviruses (PRUBVs), an emerging group of bat-derived paramyxoviruses that pose a potential global health...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $648,924 to Iowa State University of Science and Technology to conduct research on the role of mosquito extracellular vesicles in malaria parasite killing and immune system priming. The overarching objective is to obtain a mechanistic understanding of how these extracellular vesicles influence mosquito immune...
This Project Grant award of $892,050.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Missouri at Kansas City (UMKC) to investigate how plant viruses modulate host chromatin dynamics and gene expression. The key objectives are to: Determine how the PEMV2 virus P26 protein induces chromatin compaction and alters host gene expression, potentially repressing...
This Project Grant award, valued at $792,687.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the structural features of sialoglycans necessary for influenza A virus (IAV) infection and adaptation across various host species. The key activities under this award include: 1) using CRISPR/Cas9 techniques to truncate different types of sialoglycans in human lung...
This $188,980 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to elucidate the role of intestinal M cells in rotavirus enteric infection, systemic dissemination, and pathogenesis. The project aims to determine the extraintestinal tissues and cell types targeted by rotavirus following oral inoculation, and utilize genetically-modified mice lacking intestinal M cells to study the role of...
This $2,074,701 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is funding a multi-year research program at Emory University to advance understanding of the biological and physical drivers of influenza A virus transmission in humans. The key objectives of the research program are to: 1) Define the dynamics of viral load, immune responses, and infectious aerosol production in humans...