This Cooperative Agreement award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $4,000,000.00 in funding from February 1, 2025 to January 31, 2030 to The Broad Institute, Inc. to characterize the human virome. The project aims to develop a systematic, multimodal approach to map and understand the diversity of viruses present in humans, leveraging a cohort of 4,000 participants across the United States. Key activities include...
The U.S. National Institutes of Health (NIH) awarded a $4,399,999 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to The Leland Stanford Junior University to comprehensively identify and characterize the human-associated virome. The 5-year project, titled "VAST CENTER: VIROMES ACROSS SPACE(S) AND TIME", aims to advance understanding of the human virome by accessing unique, well-phenotyped cohorts, exploring diverse lifestyles, engaging with...
The U.S. Department of Health and Human Services' National Institutes of Health (NIH) awarded a $1,152,096 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to Battelle Memorial Institute's Pacific Northwest National Laboratory. The purpose of this project is to develop enhanced computational tools and pipelines to vastly improve identification and characterization of viral elements impacting the human microbiome. Key focus areas include using graph assemblies...
This Cooperative Agreement award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $4,000,000 in funding to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, from February 1, 2025 to January 31, 2030. The project, titled "The Oro-Respiratory-Gut Virome Axis Over Space and Time", aims to comprehensively characterize the human virome and its dynamics...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $233,250 to the University of North Carolina at Chapel Hill to perform key proof-of-concept research on a novel bacteriophage-based delivery platform for microbiome engineering. The goal is to develop and characterize self-circulating non-replicative phage vectors (SCNRPVs) capable of safely and efficiently transducing...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $793,247 to the University of North Carolina at Chapel Hill to conduct research aimed at improving the health of people living with HIV across the lifespan. The key products and services to be delivered include: Developing and implementing a data-driven algorithm to assign validated causes for hospitalizations among people with HIV, and using...
This Cooperative Agreement award from the National Institutes of Health (NIH) under CFDA 93.310 Trans-NIH Research Support program provides $2,255,898 in funding to the University of California, San Francisco (UCSF) to conduct a comprehensive study of the human virome across multiple organ systems. The study aims to characterize the anatomical, histological, and cellular distribution of viruses in the human body, as well as their relationship to host immune and inflammatory responses. The...
This Project Grant award, valued at $792,687.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the structural features of sialoglycans necessary for influenza A virus (IAV) infection and adaptation across various host species. The key activities under this award include: 1) using CRISPR/Cas9 techniques to truncate different types of sialoglycans in human lung...
This federal Cooperative Agreement award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, funds the development of two novel tools for the Human Virome Project. Aim 1 is focused on creating a virus purification pipeline that can achieve sensitivity of less than 1 genome copy per milliliter using larger sample volumes. Aim 2 will develop a single virion detection pipeline to provide an accurate...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $427,625 to the University of North Carolina at Chapel Hill to advance the understanding of ethical, legal, and social implications (ELSI) of human virome research. The 2-year project aims to: 1) conduct a multidisciplinary horizon scan to identify high-priority ELSI topics in virome research, 2) develop vignettes of potential clinical and public health applications of virome research to collect expert input, and 3) produce and disseminate ELSI resource guides for viromics research teams and trainees. This work is intended to illuminate ELSI and policy implications as the field of human virome research rapidly expands.