Project Grant R21AI188192
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $406,450 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Harvard T.H. Chan School of Public Health. The grant supports research to develop a continuous in vitro culture system for the Plasmodium vivax malaria parasite. Key objectives include optimizing the production of host reticulocytes (young red blood cells) to support P. vivax growth, iteratively improving culture conditions...
- The Project Grant award R01AI187153 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on identifying genetic factors associated with sexual stage development (gametocyte formation) in the malaria parasite Plasmodium falciparum. The $700,288 award, with a project period from Nov 2024 to Oct 2029, will fund a research project at the University of South Florida to perform...
- This Project Grant award of $190,261 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund a longitudinal cohort study on Plasmodium vivax (PV) malaria relapses in Central Africa. The study aims to understand the proportion of PV infections that have relapses, the periodicity of relapses, the genetic diversity of relapse parasites compared to primary infections, and the potential for relapse infections to contribute to...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The $420,750 award to Iowa State University of Science and Technology supports research to elucidate the role of the PfHAP2P2 protein in the sexual reproduction and fertilization process of the malaria parasite Plasmodium falciparum. The researchers aim to delineate the functional importance and cell...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,808 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The funding will support research to identify heme-binding proteins in the malaria parasite Plasmodium falciparum and investigate their role in maintaining heme homeostasis. The project aims to better understand how the parasite detoxifies heme, an essential but redox-active...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $385,816 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Iowa State University of Science and Technology to conduct research on disrupting the DNA replication of the malaria parasite Plasmodium's apicoplast. The research aims to identify and characterize key proteases involved in processing the essential PREX protein needed for apicoplast DNA replication, in order to inform the...
- This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $107,542 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in Missouri. The grant, effective September 1, 2025 through August 31, 2027, aims to unravel the mechanisms underlying the differential sorting and trafficking of Plasmodium falciparum secreted proteins during the symptomatic stage of malaria. The research seeks to determine how exported proteins...
- This $451,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support the development of a comprehensive, high-resolution array to analyze antibody responses to variant Plasmodium falciparum antigens in populations naturally exposed to malaria. The research team at the University of California, San Francisco will leverage advanced bioinformatic and laboratory methods to create...
- This Project Grant award of $699,814 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, aims to study molecular mechanisms of Plasmodium parasite invasion in Anopheles mosquito midguts to identify novel targets for transmission-blocking malaria vaccines. The key products and services to be delivered under this award include: Functional characterization of identified mosquito and parasite proteins that mediate...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $437,625 Project Grant to Colorado State University to support research on "Understanding Plasmodium vivax Transmission Networks Through a Novel Microhaplotype and Kinship Analysis Approach". The research aims to assess the effectiveness of reactive case detection (RCD) as a malaria control strategy in low transmission areas by using high-resolution genomic data to analyze transmission networks. The project will leverage highly multiplexed amplicon sequencing of microhaplotype markers to genotype Plasmodium infections and resolve kinship relationships, accounting for the unique epidemiological factors that impact such analyses. The grant is effective from August 1, 2025 through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.6k | 7/29/25 |