Project Grant R21AI188100
- This Project Grant award of $480,249.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to investigate the role of the extracellular matrix (ECM) as a determinant of infectivity for the filoviruses Ebola (EBOV) and Marburg (MARV). The research aims to understand how ECM composition and stiffness impact the ability of these deadly viruses to...
- This $536,871 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify small molecule inhibitors against critical components of arenaviruses, which cause severe hemorrhagic fevers. The proposed studies aim to use machine learning and molecular screening to identify pan-reactive inhibitors targeting the arenavirus surface glycoprotein and RNA polymerase...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $653,693 Project Grant to Emory University to conduct structural investigations of the HIV-1 virion and the mechanism of the capsid targeting compound lenacapavir. The research aims to leverage advanced cryo-electron microscopy and tomography techniques to study the structural details of immature HIV-1 assembly and the mechanistic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $441,100 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Mayo Clinic to develop mouse models for studying the life cycle of the Ebola virus (EBOV) under Biosafety Level-2 (BSL-2) conditions. The grant, with a performance period from August 2025 to July 2027, aims to generate two approaches for in vivo EBOV life cycle modeling using virus-like particles and expression of...
- This federal Project Grant award of $422,814.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The project aims to develop and apply adversarial machine learning methods to predict the risk of animal viruses spilling over into humans, accounting for virus evolution. Key objectives include (i) predicting human-infection risk for viral sequence variants, (ii) characterizing and...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, provides $138,213 to The Trustees of Princeton University to conduct research on viral genetic interactions and mutations. Specifically, the research aims to systematically study the molecular mechanisms by which 4 strains of the lymphocytic choriomeningitis virus (LCMV) cause distinct impacts on the liver and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,486 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The New York Structural Biology Center, Inc. (NYSBC) to conduct research on the structural diversity and functional implications of viral RNA translation initiation elements, known as internal ribosome entry sites (IRES). The research aims to define the structural heterogeneity of HCV-like IRES elements across multiple...
- This Project Grant award of $128,052.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to study the role of the Rift Valley Fever Virus (RVFV) nonstructural small (NSS) protein in inhibiting the host autophagy pathway. The research will identify the impact of the NSS-LC3 interaction on autophagy, viral replication, and pathogenesis. Key objectives include confirming the NSS-LC3...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $859,992 Project Grant to Yale University for the "Molecular Investigations of HIV-1 Maturation Pathways and Inhibitor Actions in situ" research project. The grant, funded under NIAID's Allergy and Infectious Diseases Research Program (CFDA 93.855), aims to use advanced in-situ cryo-electron microscopy and tomography techniques to visualize the structural transitions of the HIV-1 virus during the maturation...
- This $3,170,096 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to develop the L7AE protein as a therapeutic for treating infections caused by the Orthomyxoviridae virus family, which includes influenza. The key research aims are: (1) investigating the mechanism of action of L7AE on various Orthomyxoviridae family members, (2)...
This federal Project Grant award, valued at $449,625.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to determine the morphology of the Lloviu virus (LLOV) virions and compare their structures to those of Ebola virus (EBOV) and Marburg virus (MARV). The research team will utilize cryogenic electron microscopy and tomography techniques to generate three-dimensional structures of LLOV virions, including isolated viral nucleocapsids. This foundational knowledge on the structural diversity of filovirus virions and nucleocapsids could inform the development of small molecule inhibitors targeting critical protein-protein interaction domains. Additionally, the research will provide novel insights into the spatio-temporal morphology of viral replication factories within LLOV- and EBOV-infected cells using electron tomography. The project period runs from September 11, 2025 to May 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $449.6k | 9/11/25 |