Project Grant R21AI188044

Award Date 8/1/25
Completion Date 7/31/27
Dollars Obligated $451K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Arkansas, USA
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This $450,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the role of different lung macrophage subsets in the maintenance of tuberculosis (TB) lesions and the local environment of Mycobacterium tuberculosis (MTB) infection.

The research team at the University of Arkansas for Medical Sciences will utilize novel metabolic analysis and spatial transcriptomics approaches to elucidate how alveolar macrophages and interstitial macrophages differentially contribute to lesion biology and local MTB growth control within necrotic granulomas in a mouse model that recapitulates key features of human TB disease. They will also delineate the relationship between macrophage subsets and the local MTB environment and activity at the single bacterium level. This work aims to provide a conceptual framework for understanding how the spatial distribution and permissiveness of lung macrophage subsets impact the local MTB environment and growth within TB lesions.

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