This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,503,349 to the University of Arkansas for Medical Sciences (UAMS) to study the ontogeny (origin) and metabolism of lung alveolar macrophages and their role in tuberculosis (TB) infection. The overarching goal is to understand how the origin and metabolic pathways of these immune cells impact their permissiveness to Mycobacterium tuberculosis, the causative agent of TB, in order to develop new therapeutic and vaccine strategies. The 5-year project, starting in August 2024, will utilize multidisciplinary approaches including immunology, metabolism, genomics, and microbiology to determine how alveolar macrophage ontogeny and metabolism regulate their response to TB infection. The knowledge gained is expected to enable the reprogramming of these macrophages to enhance control of TB at the early stage of infection.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $733.4k | 6/25/25 | ||
| Not listed | $769.9k | 8/13/24 |