The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $707,534 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center. The grant supports research to investigate the mechanisms by which the ZFAND6 protein regulates mitophagy, inflammation, and the NLRP3 inflammasome. The research aims to provide new insights into the...
This federal Project Grant award of $382,500.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tulane University. The funding supports a 5-year research project to investigate the role of nuclear cyclic GMP-AMP synthase (cGAS) in the DNA sensing signaling pathway and elucidate the regulatory mechanisms of nuclear cGAS. The research aims to determine the mechanisms controlling cGAS...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $423,803 to the University of Maryland, College Park from July 2025 through June 2027. The grant supports research to define the interactions between the host protein Stimulator of Interferon Genes (STING) and rhinovirus replication, with the goal of elucidating the mechanisms by which STING facilitates efficient rhinovirus infection. The...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 Allergy and Infectious Diseases Research, provides $3,204,624.00 to the University of Pennsylvania to define the molecular and cellular mechanisms of non-canonical inflammasome responses to lipopolysaccharide (LPS) in mice and humans. The goal is to provide essential insight for developing improved therapeutics to reduce human sepsis and enhance immune responses to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,426 to The Children's Hospital of Philadelphia (CHOP) to conduct research on chronic STAT3 signaling and its impact on CD8 T cell dysfunction. The key objectives are to investigate the role of the CD39/adenosine axis in impairing CD8 T cell function in the context of STAT3 gain-of-function (GOF) disease, and to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $831,872 to the University of Virginia and the University of Southern California to investigate the role of the STING pathway and its crosstalk with the endoplasmic reticulum (ER)-associated degradation (ERAD) mechanism in the pathogenesis of Alzheimer's disease (AD). The award will fund research to delineate how the ERAD-STING axis influences amyloid metabolism, neuroinflammation, and AD...
This federal Project Grant award of $183,701 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award will support a research project at the University of Pittsburgh titled "Identification of Post-Translationally Modified Antigens Using Genetic Code Expansion". The project aims to develop a scalable platform for presenting thousands of epitopes with precisely defined...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $971,109 over approximately 3 years starting June 2025 to researchers at the University of California, Merced. The project will study the binding dynamics and oligomerization of DNA sensor proteins AIM2 and IFI16, which are involved in pathogen detection and inflammatory signaling. Using advanced microscopy techniques,...
This Project Grant award of $318,428, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research at Swarthmore College to elucidate the mechanisms and consequences of nucleic acid sensing in human erythroid progenitors. The research aims to investigate both DNA-sensing and RNA-sensing pathways utilized by erythroid progenitors to contribute to antiviral host defense, as well as characterize the downstream...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $578,093 to the University of Massachusetts Medical School to conduct research on a novel human damage-associated molecular pattern (DAMP) receptor, its murine counterpart, and their ligand, GAPDH. The research aims to elucidate the structure, function, and pathophysiology of this DAMP receptor system in both humans...