Project Grant R21AI187752

Award Date 8/1/25
Completion Date 7/31/27
Dollars Obligated $428K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Chapel Hill, NC 27599, USA
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This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $427,625 to the University of North Carolina at Chapel Hill to investigate the role of Klebsiella pneumoniae fimbriae in liver abscess formation. The project aims to elucidate how the type 1 and type 3 fimbriae, which are surface-expressed protein appendages, contribute to the pathogenesis of...
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The University of North Carolina at Chapel Hill was awarded a $427,625 Project Grant by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study the factors contributing to treatment failure of hypervirulent Klebsiella pneumoniae liver abscesses. The research aims to: 1) use quantitative and imaging mass spectrometry to visualize antibiotic distribution and the role of antibiotic-tolerant cells in treatment failure, and 2) employ RNA sequencing to examine the transcriptional profile of K. pneumoniae in wound infection versus liver abscesses and assess the ability of virulence factor mutants to establish infection. This project, which runs from August 2025 to July 2027, seeks to improve understanding of this clinically challenging indication and aid in the development of future therapeutic interventions.

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