Project Grant R21AI186048

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $466K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
New York, USA
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This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $466,125 to Rockefeller University to conduct research on the genetic basis of isolated congenital asplenia (ICA).

The key objectives of this 2-year award, which runs from July 1, 2025 to June 30, 2027, are to: 1) identify genetic factors that contribute to the incomplete penetrance of ICA caused by RPSA haploinsufficiency, 2) discover new genetic etiologies of ICA, and 3) investigate how RPSA haploinsufficiency impacts the translation of specific mRNAs. This research aims to provide a better understanding of the mechanisms underlying this rare developmental defect affecting the spleen, and lay the groundwork for future studies on the function of human ribosomal proteins.

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