Project Grant R21AI185834
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $817,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Vermont & State Agricultural College. The grant, awarded on July 9, 2025, supports the development of new tools to study how the Toxoplasma gondii parasite delivers its "effector" proteins into host cells during the invasion process. This research aims to understand the mechanisms by which T....
- This federal Project Grant award of $563,513.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The funding supports research at Arizona State University to investigate the patterning, growth, and maturation of the cortical microtubules in Toxoplasma, a unicellular parasite that causes diseases such as toxoplasmosis. The research aims to explore the initiation of patterning...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $435,875 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Merced. The grant, titled "Interrogating NFKBID Dependent Humoral Immunity to Toxoplasma gondii", seeks to understand the mechanisms by which the transcriptional regulator IKBNS (encoded by NFKBID) mediates protective immunity against the parasitic infection Toxoplasma gondii. The...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $133,693 to the Fundacion Instituto De Investigaciones Biotecnologicas in Argentina to study the role of an unusual variant nucleosome in the life cycle of the Toxoplasma gondii parasite. The research aims to investigate how epigenetic changes in T. gondii's unique H2A.Z/H2B.Z double-variant nucleosome...
- This $423,500 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 22, 2025. The grant supports research to identify the molecular targets of the anti-parasitic compound Tartrolon E and determine if inhibition of the identified target proteins mediates the compound's broad anti-apicomplexan activity. The research aims to characterize the role of two rhoptry proteins,...
- This federal Project Grant award of $214,742 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify and characterize Toxoplasma gondii (T. gondii) proteins that facilitate the parasite's ability to cross the placental barrier and cause congenital infection. The research team at Texas A&M University will use innovative in vitro models and pregnant guinea pig studies to test the role...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research, will support research to investigate the genetic mechanisms that determine host susceptibility to low virulence strains of the Toxoplasma gondii parasite in mice. The $269,054 award, effective November 8, 2024 through October 31, 2026, will enable researchers at the University of California, Merced to leverage the...
- This Project Grant award of $418,016 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research CFDA program supports research to explore the evolutionary origins of intracellular parasitism in apicomplexan organisms. The award aims to establish molecular and cellular mapping of the photosynthetic algae Chromera velia, which is closely related to apicomplexan parasites like those causing malaria and toxoplasmosis. Specifically, the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $847,000 Project Grant through the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Kentucky Research Foundation. The purpose of this 2.5-year award, beginning July 2025, is to investigate the protective roles of the CD180 and NOD1 molecules in the immune response against cerebral Toxoplasma gondii infection. The research aims to better understand how these pathogen-associated molecular...
- This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,456,732 to support research on Toxoplasma gondii infection in people living with HIV/AIDS (PLWHA). The research aims to understand the mechanisms behind the parasite's ability to cause latent infections in the central nervous system and reactivate, leading to toxoplasma encephalitis - a significant cause of...
This Project Grant award of $427,604 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the molecular mechanisms of conoid extrusion in the pathogen Toxoplasma gondii. The goal is to reconstitute the core elements of the parasite's apical complex, including actin, myosin, and a formin, in vitro to gain a mechanistic understanding of how the conoid structure is extruded during cell motility and host cell invasion. The research aims to study the biophysical properties of the myosin and formin proteins, as well as visualize their cooperative interactions with actin to drive conoid extrusion. Findings from this work are expected to inform the development of next-generation drugs targeting these essential proteins for the treatment of toxoplasmosis, a disease that chronically infects a third of the world's population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 8/19/25 |