Project Grant R01AI184433

Award Date 4/22/25
Completion Date 3/31/30
Dollars Obligated $564K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Arizona, USA
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $868,000 in funding to the Trustees of Boston College to investigate the early stages of the division process in the Toxoplasma gondii parasite, which causes tissue lesions in humans. The research aims to establish the role of the gamma-tubulin complex in nucleating the parasite's specialized cytoskeleton, called the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $269,054 to the University of California, Merced to conduct research on mechanisms that determine disease outcome following primary infection with the Toxoplasma gondii parasite. The research aims to leverage the Collaborative Cross mouse panel and parasite genetics to dissect novel host-parasite interactions...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $176,537 Project Grant to the CAL Poly Pomona Foundation Inc. The grant, awarded on July 24, 2024, aims to investigate the role of reactive oxygen species (ROS) in controlling acute Toxoplasma gondii infection. The research project will: 1) determine the cellular events required to induce ROS in T. gondii-infected neutrophils, 2) identify the...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to study protein glycosylation and trafficking in the malaria parasite Plasmodium falciparum. The total funding amount is $1,333,629.00, spanning from the award date of June 6, 2024 to the ultimate completion date of April 30, 2029. The research project will combine genetic and cellular assays to investigate...
This federal Project Grant award, totaling $791,864 and running from December 1, 2024 to November 30, 2029, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The primary goal of the research project is to identify the molecular factors that control chromatin organization and gene regulation in the Plasmodium falciparum parasite, the causative agent of the most severe form of human malaria....
This $684,000 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research into non-competitive inhibition of the CYP121 enzyme from Mycobacterium tuberculosis. The key objectives are to investigate the enzyme's distal-to-distal homodimer interface as a potential target for novel anti-tuberculosis therapeutics, and to develop pharmacophores that can inhibit CYP121...
This $153,512 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand and overcome immune evasion mechanisms used by Plasmodium parasites, the causative agents of malaria. The research aims to characterize the memory B cell response to the circumsporozoite protein (CSP) antigen, which is the target of currently deployed malaria vaccines, in order to identify...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $375,988 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Whitehead Institute for Biomedical Research. The purpose of this 3-year research project is to investigate the molecular mechanisms underlying the transition and reactivation of the chronic stage of the Toxoplasma gondii parasite. The research aims to uncover how a specific transcription factor (BFD1) and an upstream...
This Project Grant award, valued at $862,400 and made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate an essential mechanism for iron uptake by the Plasmodium parasite's apicoplast organelle. The research, conducted by the University of Utah, will use CRISPR/Cas9 to investigate the role and sub-organellar localization of a putative iron transporter protein (PF3D7_1248300) in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $147,656 to investigate the molecular architecture of the host-parasite interface for the pathogen Cryptosporidium. The research aims to uncover the three-dimensional ultrastructure, molecular composition, and functional mechanisms governing how this intracellular parasite interacts with and manipulates its host cells to...

This federal Project Grant award for $563,513.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at Arizona State University (ASU) to investigate the patterning, growth, and maturation of the cortical microtubules in the Toxoplasma parasite. The research aims to explore the initiation of patterning (Aim 1) and the growth and maturation (Aim 2) of the microtubule array in this apicomplexan parasite, which causes diseases like toxoplasmosis. This project will generate new insights into the mechanisms underlying the assembly of complex cytoskeletal frameworks in these parasites, potentially leading to the discovery of new druggable, parasite-specific targets for treating toxoplasmosis. The award period runs from April 22, 2025 to March 31, 2030.

Generated 4/29/25, 2:47 AM