This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of self-recirculating, non-replicating bacteriophage (phage) vectors as a platform for targeted gene therapy of the human microbiome. The $233,250 award, effective from May 13, 2025 to April 30, 2027, aims to produce and characterize various self-contained non-replicative phage vectors (SCNRPVs) and benchmark their in vivo delivery efficiency against replicative phages, conventional non-replicative phages, and engineered bacteria. The goal is to provide proof-of-concept data motivating further exploration of these engineered phages as tools for targeted genetic manipulation of specific microbial species within complex microbiomes, without the risk of horizontal gene transfer. The work will be conducted by the University of North Carolina at Chapel Hill, a prominent public research university with extensive experience executing federally-funded projects across various disciplines.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $233.3k | 5/13/25 |