Project Grant R21AI185574
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $165,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tufts University School of Medicine for the development of an improved transposon mutagenesis system to enable comprehensive genetic analysis of Borrelia burgdorferi, the bacterium that causes Lyme disease. The project aims to create a high-efficiency transposon insertional mutagenesis system for B. burgdorferi to...
- This $2,494,866 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize innate immune signaling pathways in the tick Ixodes scapularis. The project aims to improve understanding of immune signaling in ticks, which are vectors of Lyme disease and other emerging infectious diseases. The research will combine cell culture-based methods with in vivo assays...
- This Project Grant award of $518,099 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), with a performance period from July 17, 2025 to June 30, 2030. The award supports research at the University of Maryland, College Park to investigate a cross-species communication pathway that enables ticks of the Ixodes scapularis species to sense and respond to mammalian-derived factors,...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,315,179 to Tufts University School of Medicine to conduct research on the microbial determinants of excessive inflammation and severe Lyme disease. The researchers will leverage a unique collection of clinical samples and isogenic Borrelia burgdorferi strains to systematically delineate the immunogenic...
- This Project Grant award of $192,500.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to identify key mechanisms of how the Lyme disease-causing bacteria Borrelia burgdorferi invades the central nervous system. The research aims to develop a reproducible small animal model of Lyme neuroborreliosis, which has been a critical gap in understanding the pathology of Lyme...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $461,375 to Yale University to systematically identify interactions between Lyme disease bacteria (Borrelia burgdorferi) and the extracellular, secreted, and transmembrane proteins of the tick vector Ixodes scapularis. The goal is to develop a better understanding of the critical pathogen-vector...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), will fund research to characterize the roles of tick inhibitors of metalloproteases in the transmission of the Lyme disease agent by blacklegged ticks. The $423,106 award to Texas A&M AgriLife Research, a component of the Texas A&M University System, will enable two specific aims: 1) unveiling the protease...
- This federal Project Grant award in the amount of $640,129 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Connecticut Health Center (UCHC). The purpose of the grant is to conduct research on deciphering the regulatory networks of the Borrelia burgdorferi (BB) bacterium, which causes Lyme disease, as it transitions between tick vectors and mammalian hosts. Key areas...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $431,143 Project Grant to Tufts University School of Medicine under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of this 3-year grant, beginning January 23, 2025, is to develop methods for continuous in vitro propagation of the parasite Babesia microti, which is responsible for increasing rates of human babesiosis in the Northeastern U.S. Specifically, the grant will fund research to...
- This federal Project Grant award of $232,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate antimicrobial product biosynthesis in the blacklegged tick endosymbiont Rickettsia buchneri. The research aims to understand the role of R. buchneri in preventing pathogenic rickettsial superinfection of its tick host, Ixodes scapularis, which is the major vector of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $417,845 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Nebraska Medical Center (UNMC) to adapt an in vitro human skin model for studying Borrelia burgdorferi transmission and colonization by the blacklegged deer tick (Ixodes scpaularis). The project aims to modify the skin model to increase tick feeding efficiency, demonstrate B. burgdorferi transmission and acquisition by nymphal ticks, and characterize the kinetics of bacterial growth and spread within the organotypic skin following direct injection. The novel skin model will enable new research on Lyme disease and other tick-borne diseases, reducing the need for animal testing. The project will be carried out from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $417.8k | 7/31/25 |