Project Grant R01AI181904
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $165,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tufts University School of Medicine for the development of an improved transposon mutagenesis system to enable comprehensive genetic analysis of Borrelia burgdorferi, the bacterium that causes Lyme disease. The project aims to create a high-efficiency transposon insertional mutagenesis system for B. burgdorferi to...
- This $2,494,866 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize innate immune signaling pathways in the tick Ixodes scapularis. The project aims to improve understanding of immune signaling in ticks, which are vectors of Lyme disease and other emerging infectious diseases. The research will combine cell culture-based methods with in vivo assays...
- This federal Project Grant award in the amount of $640,129 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Connecticut Health Center (UCHC). The purpose of the grant is to conduct research on deciphering the regulatory networks of the Borrelia burgdorferi (BB) bacterium, which causes Lyme disease, as it transitions between tick vectors and mammalian hosts. Key areas...
- This Project Grant award of $509,130 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of South Florida to investigate the global virulence regulatory network of the Lyme disease pathogen Borrelia burgdorferi. The key objectives are to: 1) Define the BosR regulon and characterize how BosR-regulated genes contribute to the infectious cycle of B. burgdorferi; 2) Examine the biological roles of...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $461,375 to Yale University to systematically identify interactions between Lyme disease bacteria (Borrelia burgdorferi) and the extracellular, secreted, and transmembrane proteins of the tick vector Ixodes scapularis. The goal is to develop a better understanding of the critical pathogen-vector...
- The Virginia Commonwealth University was awarded a $746,009 Project Grant from the Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases. The grant falls under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research examining the cyclic-di-GMP signaling pathway and its role in the enzootic cycle of Lyme disease from November 18, 2022 through October 31, 2027. Specifically, the grant will fund...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $191,250 to Washington State University (WSU) to conduct research on the immune evasion mechanism of the Lyme disease spirochete, Borrelia burgdorferi. The award supports mechanistic studies on the role of genetic factors in the antigenic variation of the VlsE surface protein, a key mechanism for persistent...
- The federal Project Grant award of $162,000 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to characterize the binding of epidermal growth factor (EGF) to the Lyme disease bacterium Borrelia burgdorferi and the resulting transcriptional regulation. The research aims to expand the understanding of how B. burgdorferi senses and responds to host environmental cues,...
- This Project Grant award of $192,500.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to identify key mechanisms of how the Lyme disease-causing bacteria Borrelia burgdorferi invades the central nervous system. The research aims to develop a reproducible small animal model of Lyme neuroborreliosis, which has been a critical gap in understanding the pathology of Lyme...
- This Project Grant award of $518,099 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), with a performance period from July 17, 2025 to June 30, 2030. The award supports research at the University of Maryland, College Park to investigate a cross-species communication pathway that enables ticks of the Ixodes scapularis species to sense and respond to mammalian-derived factors,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $3,315,179 to Tufts University School of Medicine to conduct research on the microbial determinants of excessive inflammation and severe Lyme disease. The researchers will leverage a unique collection of clinical samples and isogenic Borrelia burgdorferi strains to systematically delineate the immunogenic lipoproteins and ascertain their function in dysregulated immune responses and adverse clinical outcomes in Lyme disease. This 4-year project aims to improve understanding of the microbial factors that contribute to the range in Lyme disease severity and identify potential biomarkers to predict which patients are at greater risk for adverse outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 9/16/25 |