The University of Louisville received a $206,801 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to study the complex population dynamics that characterize chronic HIV infection. The 2-year project will develop a novel statistical phylogenetic tool (GOSIP) and framework to identify cooperative behavior through compensatory evolution in HIV/SIV virus populations. This innovative approach aims to improve understanding of factors driving HIV persistence in the face of immune and therapeutic defenses, with the goal of informing new treatment strategies for chronic viral infections. The research will analyze full-genome sequence data from an existing cohort of extensively sampled SIV-infected macaques.
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