This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $291,368 to Northwestern University to investigate the role of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in regulating R-loops during human papillomavirus (HPV) replication. The project aims to study why DNA-PK activation is important in the HPV lifecycle and analyze how DNA-PK mitigates R-loop...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports a $453,429 research project on the "Regulation of RNA Editing in Two Life Cycle Stages of Trypanosoma brucei". The 5-year project aims to investigate the key proteins and mechanisms involved in differential RNA editing across the life cycle of this pathogenic kinetoplastid protozoan, which alternates between mammalian...
This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $242,185 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M Agrilife Research. The grant supports research to investigate the role of RNA structure in regulating developmental RNA editing in pathogenic trypanosomes, such as Trypanosoma brucei. The key objectives are to: 1) Develop a new technique to assess RNA structure under native cellular conditions versus in vitro,...
This Project Grant award of $734,184 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to elucidate the mechanisms of parainfluenza virus genome replication. The primary awardee, Trustees of Boston University, will conduct structure-guided analysis of the viral polymerase complex to understand how it regulates the balance between transcription and replication. The team will also investigate how viral...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $431,143 to Tufts University School of Medicine to develop methods for continuous in vitro propagation of the parasite Babesia microti. The goal is to enable new drug development and improve understanding of the biology of this parasite, which has led to increased human babesiosis cases in the Northeastern United...
This Project Grant award of $438,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop new tools to facilitate drug discovery for pathogen proteasomes. The funded project at the University of California, San Diego aims to address two key bottlenecks in advancing research on parasite proteasomes - the difficulty in isolating and purifying parasite 20S proteasome enzymes,...
This Project Grant award of $877,104 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports research to investigate the interactions between Kaposi's sarcoma-associated herpesvirus (KSHV), mononuclear phagocytes, and B cells, and how KSHV establishes long-term latency in B cells. The research, conducted by Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, will use computational...