The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,498,642 Cooperative Agreement under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Oregon Health & Science University (OHSU). The objective of this 5-year award is to conduct a pragmatic, multi-arm, randomized clinical trial comparing clinical outcomes across specific biologic medications used to treat chronic rhinosinusitis with nasal polyps (CRSWNP). The study aims to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation (doing business as Massachusetts General Hospital) to establish a CRISPR-based airway organoid platform for screening mechanisms involved in airway epithelial cell and intraepithelial airway macrophage interactions. The goal is to identify novel mediators of airway immune cell homeostasis,...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research aimed at understanding the mechanisms underlying mast cell expansion and function in human airway diseases, including asthma and nasal polyposis. The $715,968 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated, will fund a 5-year project to investigate the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $486,109 to the Mayo Clinic Arizona to investigate the role of eosinophils and type 2 immune responses in acute lung injury and acute respiratory distress syndrome (ALI/ARDS). The research aims to define how increasing type 2 immune responses of eosinophils through IL-33 activation or suppression of the IRF1...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $458,634 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Cincinnati. The goal of this 2-year project (8/1/2025 - 7/31/2027) is to conduct a multi-ancestry genome-wide association analysis and develop polygenic risk scores to identify genetic variants specifically associated with moderate-to-severe asthma, which accounts for a significant portion of...
This Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $443,527 to Brigham & Women's Hospital, Inc. to conduct translational research to advance the understanding and clinical care of antibiotic-induced delayed-type drug hypersensitivity reactions. The project aims to investigate potential "X-factors" that may critically drive the onset, phenotype,...
This Project Grant award, valued at $730,392, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research conducted by the University of Colorado-Denver to investigate the role of adipose tissue and eosinophils in regulating airway function and inflammation in lean and obese mice. Specifically, the research aims to determine: 1) the metabolic response of adipose tissue to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $175,000 to the La Jolla Institute for Immunology to study the role of Alternaria fungal sensitization in asthma pathogenesis. The research aims to determine the association between Alternaria-specific T cells and protection against Alternaria sensitization, as well as identify Alternaria-specific T cell...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...