The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $710,018 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Dartmouth-Hitchcock Clinic to evaluate the use of indocyanine green (ICG) fluorescence imaging for rapid diagnosis of necrotizing soft-tissue infections (NSTIs). The project aims to conduct a prospective, observational, multicenter clinical study to assess the ability of dynamic contrast-enhanced fluorescence imaging (DCE-FI) with...
This Department of Defense (CFDA 12.420 - Military Medical Research and Development) Project Grant award of $2,499,990.00 was provided to the Dartmouth-Hitchcock Clinic, doing business as Dartmouth-Hitchcock Obligated Group, to conduct a multicenter randomized controlled trial evaluating the use of incisional negative pressure wound therapy to reduce infection and complications in high-risk fractures. The grant has an award date of September 1, 2023 and an ultimate completion date of August...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $456,864 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to evaluate the potential of a novel antimicrobial blue light (ABL) emitting envelope for controlling infections related to cardiac implantable electronic devices (CIEDs). The two-year project aims to assess the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $894,735 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to St. Jude Children's Research Hospital Inc. The grant will fund the development of a novel positron emission tomography (PET) imaging agent, [18F]fluoromannitol, to diagnose and monitor bacterial osteomyelitis in patients with sickle cell disease. Key objectives include establishing a streamlined radiosynthesis, validating...
This $105,076 Project Grant was awarded on December 20, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant supports research conducted by Trustees of Dartmouth College to investigate the dual function of the TSIT immunity protein in regulating Pseudomonas aeruginosa biofilm production, which is a key challenge in treating chronic respiratory infections in cystic fibrosis...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $661,693 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The University of Iowa. The grant, awarded on June 16, 2025, supports research to define the structure and function of a new family of peptidoglycan crosslinking enzymes found in Clostridioides difficile, an opportunistic pathogen and leading cause of hospital-acquired infectious diarrhea. The research aims to advance...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $173,030 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to President and Fellows of Harvard College. The grant, awarded on September 25, 2024, will fund the development of a novel assay for targeted isolation of environmental bacteriophages (phages) based on their receptor dependencies. The project aims to create a generalizable technique that allows selecting phages that require...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $171,254 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Nimml Institute Inc., a 501(c)(3) non-profit research organization in Blacksburg, Virginia. The grant, effective from December 1, 2024 to November 30, 2026, aims to elucidate novel immunometabolic mechanisms that intercept bacterial toxin internalization and processing to suppress cell damage caused by Clostridioides difficile...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $442,024 to Trustees of Dartmouth College to conduct research on the cellular mechanisms driving antibody effector functions. The research aims to elucidate the complex relationships between antigens, antibodies, and effector cells in order to establish design criteria for engineering antibody therapeutics with predictable and robust effector...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $126,174 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of California, Davis (UC Davis). The grant, with a performance period from May 29, 2025 to Dec 31, 2027, will support research to investigate the local immune response in bacterial skin infections using a novel skin-on-a-chip model. Specifically, the project aims to demonstrate the role of...