Structural mapping of an immunodominant antigenic site on the norovirus capsid
Active Project Grant Awarded Last action
- Award ID
- R21AI180523
- Recipient
-
University Of California Santa Cruz UEI VXUFPE4MCZH5
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $800,250
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 79% complete
- Originally
- Place of performance
- Santa Cruz, CA 95064, USA
Award details come from USAspending.gov.
Description
- Abstract
- Noroviruses are a top cause of acute gastroenteritis globally, and no approved norovirus vaccine exists. The norovirus capsid protein plays key roles in virus attachment and entry into host cells and is the target of neutralizing antibodies. Recent genomics and serological studies predict the presence of a new antigenic site, named antigenic site g, and suggest that IT became immunodominant during the emergence of the most recent GII.4 norovirus variant outbreak, revealing a novel mechanism for virus evolution immune escape. However, the molecular interactions of neutralizing antibodies targeting this immunodominant site on the norovirus capsid have not been described. Our goal is to define the epitopes that are recognized by neutralizing monoclonal antibodies targeting the immunodominant antigenic site g on the norovirus capsid and to directly visualize and map antibody immunodominance in serum antibodies targeting past and current norovirus variants. Using an integrated structural and biophysical approach, we will pursue two specific aims to (1) define the epitopes of neutralizing monoclonal antibodies targeting the norovirus capsid antigenic site g and (2) directly visualize the chronological shift in antibody immunodominance towards antigenic site g. Results obtained by this work will provide a molecular roadmap for the development of novel norovirus vaccine immunogens that broadly protect against norovirus infection and disease.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $234,750 | |
| Amendment | $19,500 | |
| Amendment | $19,500 | |
| Amendment | $175,500 | |
| Amendment | $175,500 | |
| Original award | $175,500 |
Quick answers
Who received award R21AI180523?
R21AI180523 was awarded to University Of California Santa Cruz by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on July 10, 2024.
How much is award R21AI180523 worth?
$800,250 has been obligated on R21AI180523.
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