Nitroimidazole susceptibility and mechanisms of resistance in mycoplasma genitalium
Active Project Grant Awarded Last action
- Award ID
- R21AI180339
- Recipient
-
University Of Washington UEI HD1WMN6945W6
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $427,625
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 77% complete
- Originally
- Place of performance
- Seattle, WA 98195, USA
Award details come from USAspending.gov.
Description
- Abstract
- Mycoplasma genitalium is a sexually transmitted bacterial pathogen that frequently causes genital tract syndromes including urethritis in men and cervicitis, pelvic inflammatory disease, and infertility in women. Sensitive diagnostic tests have been approved in the US since 2019, however, few treatment options for m. Genitalium are available. M. Genitalium lacks a cell wall and has only a single membrane so antibiotics targeting peptidoglycan synthesis, or the bacterial outer membrane, are completely inactive. Doxycycline is only 30-40% effective in eradicating m. Genitalium infections. The efficacy of azithromycin, the preferred therapy, has decreased in recent years and now more than 50% of US strains are resistant. In high-risk populations in the US and worldwide azithromycin resistance reaches 100%. More than 10% of strains are resistant to moxifloxacin, the recommended second line therapy, and resistance to both macrolides and fluoroquinolones is increasingly reported. No effective treatment options are approved in the US to treat these dually resistant infections. In addition, moxifloxacin is not approved for certain patient groups (e.g., pregnant women, adolescents
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $194,375 | |
| Original award | $233,250 |
Quick answers
Who received award R21AI180339?
R21AI180339 was awarded to University Of Washington by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on July 1, 2024.
How much is award R21AI180339 worth?
$427,625 has been obligated on R21AI180339.
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