Project Grant R21AI179603
- This $640,129 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to decipher the regulatory networks of the bacteria Borrelia burgdorferi in ticks and mammals. The research aims to understand how this bacteria remodels its gene expression as it moves between its tick vector and mammalian host environments. Key objectives include analyzing the RpoS regulon during the tick blood meal and...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $518,099 to the University of Maryland, College Park to conduct research on a cross-species signaling system in tick immunity and development. The research aims to define how interactions between a novel tick protein (ISCDL) and the tick cell surface receptor DOME1 impact tick immune and developmental processes, both...
- This $160,500 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of a library of Rickettsia species isolates from ticks collected in the southern U.S. and Central America. The project aims to (1) build a repository of Rickettsia isolates from over 350 ticks previously collected, and (2) conduct molecular characterization of the isolated Rickettsia species....
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), is supporting the development of an improved transposon mutagenesis system for comprehensive genetic analysis of Borrelia burgdorferi, the bacterium that causes Lyme disease. The $165,000 award to Tufts University School of Medicine aims to create high-efficiency transposon insertion libraries and utilize...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,494,866.00 to President and Fellows of Harvard College, doing business as Harvard Medical School, to conduct research to characterize innate immune signaling pathways in the tick Ixodes scapularis. The research aims to improve understanding of immune signaling in ticks, which are vectors of Lyme disease...
- This federal Project Grant award, valued at $461,375.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to systematically identify and investigate the interactions between Lyme disease bacteria (Borrelia burgdorferi) and the extracellular, secreted, and transmembrane proteins of its primary tick vector, Ixodes scapularis. The research will leverage a curated library of over...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,429 federal Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M AgriLife Research. The grant will fund research to investigate the regulation of RNA editing in two life cycle stages of the pathogenic kinetoplastid protozoa Trypanosoma brucei. The goal is to provide insights into the key proteins and mechanisms involved in the differential RNA editing that occurs as...
- This Project Grant award of $509,130 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of South Florida to investigate the global virulence regulatory network of the Lyme disease pathogen Borrelia burgdorferi. The key objectives are to: 1) Define the BosR regulon and characterize how BosR-regulated genes contribute to the infectious cycle of B. burgdorferi; 2) Examine the biological roles of...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. Department of Health and Human Services, has awarded a $531,245 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The 5-year grant, starting on January 13, 2025 and ending on December 31, 2029, will support research to investigate the structure and function of the sorting platform, a key component of the type III secretion system (T3SS) in pathogenic...
- This $3,315,179 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at Tufts University School of Medicine to investigate the microbial determinants of excessive inflammation and severe Lyme disease. The grant aims to systematically delineate the immunogenic lipoproteins of the Borrelia burgdorferi bacteria and ascertain their role in dysregulated immune responses...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $454,791 to Baylor College of Medicine to investigate the essential mechanisms of gene regulation for tick-borne relapsing fever spirochetes. The research aims to advance the scientific understanding of how these pathogenic bacteria persistently colonize the tick vector and quickly infect the human host upon transmission. Through cutting-edge genomics techniques, the researchers will characterize the gene expression patterns and regulatory mechanisms in the tick and vertebrate stages of the spirochete life cycle, with the goal of informing the development of preventative interventions that disrupt disease transmission. This critical research will be conducted from August 2025 through July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $454.8k | 8/22/25 |