This $825,988 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to leverage social determinants data and spatial data science to reduce HIV incidence in Ending the HIV Epidemic (EHE) counties across the United States. The key products and services to be delivered under this grant include: Developing transportation-based measures of PrEP accessibility at the county and zip code levels using...
This federal Project Grant award of $183,602 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to develop an HIV-1 model for use in simian studies of AIDS pathogenesis and vaccine/therapeutic development. The award recipient, the University of North Texas Health Science Center at Fort Worth, is constructing a chimeric "HSIV" virus that contains an SIV Nef fragment within an...
This $231,752 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the in vivo innate immune response to HIV-1 infection. The research aims to identify the cellular sources of cytokines released during acute HIV-1 infection and determine the functional roles of different innate immune sensors in the antiviral response. The work will utilize the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $820,845 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to New York University School of Medicine. The grant will fund a collaborative research project with the Shelby County Health Department to use mathematical modeling to inform policy decisions aimed at improving HIV outcomes across diverse settings, including New York City, Memphis, and Northwest Mississippi. The research will...
This Project Grant award of $156,251.00 was issued on August 1, 2024 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF) to assess the cost-effectiveness of HIV care in the Department of Defense (DoD) and the Veterans Health Administration (VA). The key objectives are to: 1) develop methods...
This $623,243 Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the award is to establish the RAISE (Research Alliance in Implementation Science to End HIV) Regional Consultative Hub at the University of Washington. The RAISE Hub aims to: Provide implementation science consultation services to support NIH-funded Ending the HIV Epidemic (EHE) research...
This federal Project Grant award of $793,247 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of North Carolina at Chapel Hill (UNC-CH) to improve the health of people living with HIV. The key objectives of the research project are to: 1) develop and implement a data-driven algorithm to assign validated causes of hospitalizations among people with HIV, and use...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $176,096 to the University of Illinois to develop a computational toolkit for systematically analyzing HIV drug resistance mechanisms. The goal is to enable the rational design of effective counterstrategies to overcome HIV drug resistance. The project aims to fill key gaps in the current understanding of how protein...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,224 to the University of Chicago to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to deepen the mechanistic understanding of HIV-1 assembly, maturation, and uncoating processes, which are critical for viral infectivity and inform the design of future...
This federal Project Grant award, totaling $243,713.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, with a performance period from January 27, 2025 to December 31, 2026, aims to determine the mechanisms by which HIV-infected macrophages resist antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells. Specifically, the research will characterize...
This Project Grant award, with a total funding amount of $896,136, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant supports the development of innovative computational tools and best practice recommendations for analyzing HIV-related count outcomes, such as medication adherence, substance use problems, and frailty.
Key objectives of the grant include: (1) providing simulation-based best practice recommendations on when and how to use the Marginalized Zero- and N-Inflated Binomial (MZNIB) model to evaluate proportional outcomes with floor and ceiling effects, (2) producing tutorials for implementing the MZNIB approach using real-world data from HIV intervention/prevention trials and a large HIV cohort study, and (3) developing and disseminating an open-source computational tool for the MZNIB model. The University of Washington is the primary awardee, with a sub-award to the University of North Texas Health Science Center at Fort Worth to support the project. The award period runs from June 2024 to April 2026.