Project Grant R01AA031644
Award Date
9/15/24
Completion Date
6/30/29
Dollars Obligated
$821K
Funding Federal Agency
National Institute of Allergy and Infectious Diseases
Awarding Federal Agency
National Institute on Alcohol Abuse and Alcoholism
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
New York, NY 10016, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,224 to the University of Chicago for computational investigations of HIV-1 assembly, maturation, and uncoating processes. The research aims to advance the mechanistic understanding of these critical viral life cycle stages, which could aid in the design of future antiretroviral therapies that disrupt these...
This Project Grant award for $1,314,572.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research aimed at developing a cure strategy for HIV-1 using CD4-mimetic compounds (CD4MCs) and CD4-induced antibodies (CD4I Abs). The research, conducted by Yale University, leverages the recent discovery of a new class of indoline CD4MCs that display improved antiviral potency and breadth...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $148,824 to the Research Foundation of the City University of New York (RFCUNY) over a 5-year period from August 2024 to July 2029. The goal of the research is to understand the clinical and social factors that impact HIV and COVID-19 outcomes among people with HIV (PWH), and to characterize how the COVID-19...
This $252,280 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to evaluate the role of monocyte cells in the development of an effective HIV vaccine response. The research project aims to investigate changes in monocyte gene expression following HIV infection, autoimmune disease, and vaccination, and to identify monocyte subtypes associated with antibody...
This federal Project Grant award, issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $681,278 to support research into the mechanisms driving the persistence of the HIV latent reservoir in people living with HIV on antiretroviral therapy. The key products or services to be delivered through this award include: 1) Fully characterizing the clonality distribution of intact and defective HIV...
This federal Project Grant award of $696,828, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the structural basis of HIV-1 cap hypermethylation and its linkage to viral post-transcriptional control and modulation of host innate immune signaling. Key objectives include elucidating the role of the HIV-1 Rev/RRE regulatory system in cap hypermethylation, and how...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $884,322 to support research into the mechanisms that create and sustain the HIV reservoir - a population of latently infected cells that persists during suppressive antiretroviral therapy and prevents a cure for HIV. The research team, led by Dr. Reeves and collaborators at the Fred Hutchinson Cancer...
This federal Project Grant award, totaling $285,816.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The objective of this 3-year project, with a start date of September 12, 2024, is to investigate the role of ADP-ribosylation (ADPR) and its associated proteins in modulating HIV-1 latency and reactivation. The research aims to identify global proteomic changes to ADPR during HIV-1...