Project Grant R21AI179016
- This $854,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to assess post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The project will utilize novel positron emission tomography (PET) imaging techniques, such as 11C-rifampin PET, to longitudinally profile lesional characteristics and antibiotic exposures in animal models...
- This federal Project Grant award of $743,817 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to delineate T cell receptor (TCR) families associated with protection from progression to pulmonary tuberculosis (TB) disease. The research will use advanced imaging techniques like fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET-CT) to identify TB-exposed household...
- This Project Grant award of $3,145,850.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The award supports research at The Johns Hopkins University to investigate macrophage senescence as a driver of granuloma failure and necrosis in pulmonary tuberculosis (TB) and TB/HIV coinfection. Key objectives include understanding the role of stress-induced senescence in myeloid...
- This $209,408 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports a research project to characterize the role of unconventional T cell subsets in the immune response to Mycobacterium tuberculosis (MTB) infection using a non-human primate model. The goal is to gain a better understanding of these niche T cell populations in the lung granulomas during the early stages of MTB...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $897,448 to The Johns Hopkins University to conduct research on the causality of post-tuberculosis (TB) lung disease in rural Uganda. The study aims to evaluate lung function and respiratory symptoms both before and after TB diagnosis to better understand how much post-TB sequelae reflect the TB disease...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,136,143 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to study post-tuberculosis lung disease (PTLD) in youth with and without HIV globally. The project will leverage the Tuberculosis Sentinel Research Network (TB-SRN) in 11 countries to establish the prevalence of PTLD in youth, identify modifiable risk factors, and assess the impact on quality of life....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $774,881 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Johns Hopkins University on February 24, 2025. The grant will support research to investigate the use of pro-apoptotic drugs, such as navitoclax, as host-directed therapies for treating pulmonary tuberculosis (TB). The research aims to evaluate how these drugs impact lung immune response, tissue...
- This Project Grant award of $423,500 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to determine the potential of phenylalanine (Phe) biosynthesis as a novel drug target for treating tuberculosis caused by Mycobacterium tuberculosis (MTB). The award will enable the development of MTB strains that conditionally express enzymes in the Phe biosynthesis pathway, which will be used to...
- This $743,651 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to validate the use of plasma cell-free RNA (cfRNA) as a biomarker for the diagnosis of tuberculosis (TB) and monitoring of treatment. The grant will support the validation of cfRNA signatures in a large patient cohort of 1,378 adults across five countries, and the comparison of cfRNA diagnostic accuracy against...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, will support research to investigate the use of chest radiography (CXR) to identify young individuals with early stages of tuberculosis (TB) in a community-based active case-finding program in Lima, Peru. The $242,376 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will fund a 2-year study to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $446,875 to The Trustees of the University of Pennsylvania to evaluate the use of Fibroblast Activation Protein (FAP) Positron Emission Computed Tomography (FAP PET/CT) imaging to characterize lung fibrosis in adult pulmonary tuberculosis (TB) patients. The research aims to determine how changes in FAP radiographic signals during TB treatment correlate with changes in lung structural damage, a key hallmark of post-TB lung disease. This longitudinal cohort study could provide insights into the mechanisms of lung fibrosis development in TB survivors and potentially identify a novel approach for monitoring and managing this significant global health burden.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.9k | 8/26/25 |