Anti-malarial drug leads from fungi

Ended Project Grant Awarded Last action

Award ID
R21AI163960
Recipient
Awarding agency
Obligated
$571,237

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date
Originally
Place of performance
North Carolina, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
There is a need for new antimalarial drug leads, particularly for treating drug resistant malaria. Fungi have been the source of many drug leads, with penicillin and the statins as two of the most prominent examples. We hypothesize that fungi harbor antimalarial drug leads, and we are addressing this via a team with expertise in mycology (mycosynthetix/pearce), natural products chemistry (uncg/oberlies), and parasitology/malaria (UGA/kyle). In the examination of 40,000 fungal cultures from the mycosythetix library, we have implemented biological and chemical protocols to prioritize our efforts. In doing so, we have now selected 8 fungal cultures that have potent antimalarial activity, minimal cytotoxicity to mammalian cells, and do not biosynthesize common nuisance compounds (i.e. mycotoxins). That averages to the analysis of ~1 fungal culture per quarter over this 2 year project. Our team is poised to isolate, elucidate, and evaluate antimalarial drug leads from these cultures. In addition, we will prioritize the 1 to 2 best leads, such that ample materials are produced for more in depth biological evaluation.

Transactions

Action Obligated Date
Amendment -$429
Amendment $172,897
Amendment $172,897
Original award $225,872

Subawards

Subrecipient Amount Awarded
Mycosynthetix, Inc. Dr. Cedric Pearce and Mycosynthetix will provide filamentous fungi for evaluation. These will be prioritized via analyses of many types of data, including… $88,000
University Of Georgia Research Foundation, Inc. Scope of Work: 1. Conduct in vitro antimalarial assays with fungal extracts and pure compounds provided by UNCG 2. Analyze the data and provide quantitative… $117,896

Quick answers

Who received award R21AI163960?

R21AI163960 was awarded to University Of North Carolina At Greensboro by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on May 21, 2021.

How much is award R21AI163960 worth?

$571,237 has been obligated on R21AI163960.

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