Project Grant R21AG103392
Award Date 8/15/26
Completion Date 7/31/29
Dollars Obligated $599K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Rochester, NY 14611, USA
Similar Awards
- The National Institute on Aging awarded The Washington University $1,366,056 on January 1, 2026, under the Aging Research program (CFDA 93.866) to develop a biocompatible fiber implant for long-term deep-brain imaging and manipulation in mouse models of Alzheimer disease. The implant integrates photoacoustic microscopy and two-photon microscopy for simultaneous functional and molecular imaging, along with microelectrode-based neural stimulation and microfluidics-based drug delivery to create a...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded the University of Rochester $227,250 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate macrophage spatial heterogeneity in regulating hematopoietic aging and inflammation-related stem cell dysfunction. The research examines how resident macrophages in different bone marrow microenvironments regulate hematopoietic stem cell (HSC) division symmetry and fitness during aging. Using intravital microscopy and HSC reporter...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded The Johns Hopkins University $618,410 under the R21 (Exploratory/Developmental) grant mechanism on February 1, 2026, to develop a deep learning-based miniature microscope for imaging aging and Alzheimer's disease pathology in preclinical models. The project addresses imaging constraints in Alzheimer's disease research by creating hardware optimized to visualize neurovascular unit (NVU) changes—neural, vascular, and blood flow alterations—that occur early...
- The National Institute on Aging awarded the University of Pittsburgh $484,635 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop in vitro aging of cartilage in a microphysiological knee joint system. The recipient will extend the "minijoint," a microphysiological system representing critical joint tissues (cartilage, bone, synovium, adipose) and using microfluidics, to recapitulate the transition of chondrocytes from young and healthy to aged and...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $450,200 on May 15, 2026, under the Aging Research program (CFDA 93.866) to map age-dependent changes in primary sensory neurons and nociceptors. The recipient will deliver a systematic, cell-type-resolved map of how normal aging remodels peripheral sensory neurons housed in the dorsal-root ganglion (DRG). The project employs subtype-specific labeling via a recently published molecular-genetic...
- The National Institute on Aging awarded Vasoptic Medical, Inc. $500,000 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop an imaging platform for assessing neurovascular response as an early-stage biomarker for Alzheimer's disease. During Phase I, Vasoptic Medical will demonstrate proof of concept using a technology called VasoVue NV, which stimulates the mouse retina with flicker illumination and uses laser speckle contrast imaging to monitor blood flow changes....
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Trustees of Columbia University in the City of New York $636,479 on May 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the role of macrophages in intervertebral disc inflammation and degeneration. The research will identify how monocyte-derived macrophages drive disc degeneration and painful inflammation through three...