Project Grant R21AG102953
- The National Institute on Aging awarded The Research Foundation For The State University Of New York (operating as Stony Brook University) $2.017 million in project grant funding on March 15, 2026, to develop and validate cyclooxygenase-1 (COX-1) positron emission tomography (PET) imaging as a neuroinflammatory biomarker for Alzheimer's disease. The award operates under the Aging Research program (CFDA 93.866). The funded research addresses the absence of disease-stage-specific neuroinflammation...
- The National Institute on Aging awarded The Research Foundation For The State University Of New York (operating as Stony Brook University) $454,937 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the regulatory landscape of neurodegeneration using single-cell spatial multiomics approaches. The research integrates chromatin accessibility and protein-level measurements to characterize how cells near Alzheimer's disease hallmarks—amyloid-beta and tau—regulate...
- The National Institute on Aging awarded The Research Foundation for The State University of New York (operating as Stony Brook University) $557,764 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a prospective cohort study examining cognitive and physical consequences of caregiving for individuals with Alzheimer's disease and related dementias. The Stony Brook Caregivers Research Study (SBCARES) will assess cognitive fluctuations in 120 older caregivers aged 60...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $2,409,629 in Project Grant funding on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of neuronal ryanodine receptor type 2 (RYR2) in cognitive impairment associated with heart failure. The research aims to uncover the mechanisms by which cognitive impairment develops in both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced...
- The National Institute on Aging awarded the Regenerative Research Foundation $428,175 on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell (iPSC)-derived three-dimensional vascular microphysiological model for studying cerebral amyloid angiopathy and Alzheimer's disease-related vascular pathology. The recipient will establish a 3D model incorporating microglia and vascular endothelial cells within a microfluidic device to enable...
- The National Institute on Aging awarded New York University $712,578 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a prospective study identifying viral infections associated with cognition decline and Alzheimer's disease risk across three prospective cohorts. The award supports comprehensive serologic profiling using VirScan, a bacteriophage immunoprecipitation sequencing technology, to detect immune responses to human viruses and analyze antiviral antibodies in...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $704,145 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and apply computational methods for inferring the natural history of Alzheimer's disease from sparse longitudinal molecular and neuroimaging data. The recipient will develop an innovative approach that leverages temporal signal in sparse longitudinal datasets to reconstruct the timeline of Alzheimer's disease progression and...
- The National Institute on Aging awarded Yale University $1,492,886 for research into the impact of peripheral inflammation on microglia and neurons in aging under the Aging Research program (CFDA 93.866), with an award date of March 20, 2026. The research investigates how peripheral inflammation interacts with aging to increase dementia risk, testing the hypothesis that acute inflammation initially alters activity of inhibitory neurons in key cortical regions, triggering age-dependent microglial...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Albany Medical College $1.951689 million on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of inflammation-resolution pathways to address vascular contributions to cognitive impairment and dementia (VCID) in the context of atherosclerosis....
The National Institute on Aging awarded The Research Foundation For The State University Of New York (operating as Stony Brook University) $436,001 on August 5, 2026, under the Aging Research program (CFDA 93.866) to conduct a feasibility study examining neuroinflammation as a therapeutic target in heart failure-related cognitive decline. The study will enroll 12 patients ages 50–75 with heart failure and reduced ejection fraction and possible mild cognitive impairment. Researchers will use positron emission tomography imaging with the novel radioligand [11C]PS13, which selectively targets cyclooxygenase-1 in activated microglia, to quantify treatment-induced changes in brain neuroinflammation at baseline and 12 weeks after sacubitril-valsartan initiation. The study will pair PET imaging with comprehensive cognitive assessment to test the working hypothesis that sacubitril-valsartan reduces microglial-driven neuroinflammation in heart failure patients, correlating with improved cognitive performance. The project will establish feasibility for measuring neuroinflammation changes and inform future studies examining whether neuroinflammation represents a viable therapeutic target for preventing vascular contributions to cognitive impairment and dementia in cardiovascular disease. Performance occurs in Stony Brook, New York. The period of performance runs from the award date through July 31, 2028. The funding is a Project Grant, the assistance type used by the National Institute on Aging for individual investigator-initiated research projects.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $436.0k | 8/4/26 |