Project Grant R21AG101555
- The National Institute on Aging awarded the University of Pennsylvania $6.72 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to develop short RNA therapeutics targeting TDP-43 proteinopathy across amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, limbic-predominant age-related TDP-43 encephalopathy, and chronic traumatic encephalopathy. The recipient will identify and characterize short oligonucleotides that engage the TDP-43 protein,...
- The National Institute on Aging awarded The Washington University $162,000 on March 1, 2026, under the Aging Research program (CFDA 93.866) to identify and characterize new therapy targets in TDP-43 proteinopathies. The award supports research into the mechanisms by which TDP-43 mislocalization results in neuronal death and aims to discover previously unidentified therapy targets that mediate this disease process. TDP-43 pathology is observed across multiple neurodegenerative diseases...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $461,900 Project Grant to Pennsylvania State University on May 1, 2025. The grant, titled "Mechanisms Underlying TDP-43 Dependent Structural Deficits in ALS Muscles", will fund research to study the role of the TDP-43 protein in muscle degeneration associated with Amyotrophic Lateral Sclerosis (ALS). The research aims to uncover the mechanisms by which TDP-43 impacts muscle...
- The National Institute on Aging, under the Department of Health and Human Services, awarded $446,875 to the University of Pennsylvania on March 15, 2026, under the Aging Research program (CFDA 93.866) to identify short RNAs that prevent and reverse aberrant phase transitions of TAF15, an RNA-binding protein implicated in approximately 10 percent of frontotemporal dementia cases. The project, R21AG091143, funds research to develop short RNAs of 25 to 34 nucleotides that antagonize pathological...
- The National Institute on Aging awarded the University of Pennsylvania $425,235 on February 1, 2026, under the Aging Research program (CFDA 93.866) to decode antigen-specific T cells in frontotemporal degeneration. The research investigates the role of CD8+ T cells recognizing cryptic peptides derived from TDP-43 pathology in frontotemporal dementia (FTD). Approximately 50 percent of FTD cases involve TDP-43 pathology that generates cryptic exons; emerging evidence suggests these cryptic...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- Federal Project Grant Award Summary Pennsylvania State University, operating through Penn State Milton S. Hershey Medical Center, received a $432,802 project grant awarded June 1, 2025, from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year award, with completion scheduled for May 31, 2027, supports cross-validation research of gene expression changes associated...
- The National Institute on Aging awarded the Regents of the University of Michigan $126,969 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research determining the unique molecular and cellular features of limbic-predominant age-related TDP-43 encephalopathy (LATE). The recipient will compare the intrinsic properties of TDP-43 aggregates in FTLD-TDP (frontotemporal lobar degeneration with TDP-43 deposition) and LATE through high-resolution cryo-electron microscopy...
- The National Institute on Aging awarded the University of North Carolina at Chapel Hill $210,513 on July 20, 2026, under the Aging Research program (CFDA 93.866) to characterize molecular products of TDP-43 dysfunction as neuroinflammatory targets in amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). The research investigates the interplay between TDP-43 dysfunction and antigen generation that drives maladaptive neuroinflammation in ALS-FTD. The work comprises two aims:...
- The National Institute on Aging awarded the University of South Carolina $249,000 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the effects of frontotemporal dementia and amyotrophic lateral sclerosis mutations in RNA-binding proteins on mRNA transport and local translation. The research uses induced pluripotent stem cell-derived neurons with CRISPR-edited FTD/ALS mutations in RNA-binding proteins (TDP-43, FUS, HNRNPA1, HNRNPA2, MATR3, and TIA1) to determine...
The National Institute on Aging awarded Pennsylvania State University, operating as Penn State Milton S. Hershey Medical Center, $479,579 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate synaptic and metabolic alterations associated with TDP-43 proteinopathy in amyotrophic lateral sclerosis and frontotemporal dementia. The research identifies how mislocalization of TDP-43 protein from the nucleus to the cytoplasm disrupts synaptic vesicle cycling, RNA processing, and cellular metabolism—particularly glycolysis and the TCA cycle—in disease models. The recipient will use Drosophila models of TDP-43 proteinopathy and human postmortem tissues to characterize TDP-43-linked alterations in the synaptic proteome and metabolome during aging, with the goal of understanding how early synaptic and metabolic abnormalities drive disease progression prior to neurodegeneration. Preliminary proteomic work in both model systems and patient-derived induced pluripotent stem cell neurons has demonstrated that restoring HSC70-4 function rescues synaptic deficits, providing a mechanistic foundation for the proposed work. The award period runs from August 15, 2026 through July 31, 2028, with performance at Penn State Milton S. Hershey Medical Center in Hershey, Pennsylvania. This is a Project Grant, classified as an exploratory/developmental award mechanism under the Aging Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $479.6k | 8/12/26 |