Project Grant R21AG098778
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $889,728 on August 18, 2026, under the Aging Research program (CFDA 93.866) to develop circuit-based multi-focal neurostimulation targeting depression and memory in older adults with Alzheimer's dementia. The project combines transcranial direct current stimulation targeting the left prefrontal cortex to address depressive symptoms with transcranial alternating current stimulation...
- The National Institute on Aging awarded The Feinstein Institutes For Medical Research $2,557,950 on May 15, 2026, under the Aging Research program (CFDA 93.866) to investigate extracellular cold-inducible RNA-binding protein (ECIRP) as a driver of neurotoxic astrocytes in Alzheimer's disease pathogenesis and to evaluate ECIRP-targeting as a potential therapeutic approach. The research will examine the molecular mechanism by which ECIRP induces neurotoxic astrocytes and their contribution to...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- This $2,044,038 federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research into the mechanisms driving anxiety in Alzheimer's disease (AD). The project, led by New York University School of Medicine, aims to investigate the role of the thalamo-hippocampal-prefrontal circuit in AD-related anxiety. The research will use mouse models of AD to elucidate the functional synaptic architecture, in vivo neural activity, and causal impact of...
- The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
- The National Institute on Aging awarded The Feinstein Institutes For Medical Research $698,456 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop machine learning models that identify and predict delirium in hospitalized older adults. The project addresses two clinical gaps: the high rate of missed delirium diagnoses in emergency departments (over 75% missed despite intensive screening) and the need to identify high-risk patients during hospital admission to enable...
- The National Institute on Aging awarded The Research Foundation For The State University Of New York (operating as Stony Brook University) $436,001 on August 5, 2026, under the Aging Research program (CFDA 93.866) to conduct a feasibility study examining neuroinflammation as a therapeutic target in heart failure-related cognitive decline. The study will enroll 12 patients ages 50–75 with heart failure and reduced ejection fraction and possible mild cognitive impairment. Researchers will use...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded the Research Foundation For Mental Hygiene, Inc., operating through its New York State Psychiatric Institute division, $458,622 on March 1, 2026, under the Aging Research program (CFDA 93.866) to identify the impact of focused ultrasound-induced blood-brain barrier opening on brain-wide memory traces in Alzheimer's disease. The award funds research into the neuronal mechanisms of focused ultrasound combined with microbubbles (FUS-BBBO) as a novel...
- The National Institute on Aging awarded Brown University $191,409 on July 1, 2026, under the Aging Research program (CFDA 93.866) to support a K23 career development award enabling Dr. Alyssa De Vito, a research assistant professor and clinical neuropsychologist, to prepare for an independent research career focused on using digital phenotyping technologies to detect and monitor neuropsychiatric symptoms in Alzheimer's disease and Alzheimer's disease-related dementias. The project develops and...
The National Institute on Aging awarded The Feinstein Institutes For Medical Research $460,625 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanistic underpinnings of electrical trigeminal nerve stimulation for enhancing neuropsychological function in dementia. The project addresses neuropsychiatric symptoms—including anxiety and depression—that affect up to 80 percent of dementia patients and significantly contribute to cognitive decline and reduced quality of life. The research focuses on vascular cognitive impairment and dementia (VCID), the second most common dementia type after Alzheimer's disease, which is particularly vulnerable to psychological stress. The recipient will conduct mechanistic research on how electrical trigeminal nerve stimulation may alleviate neuropsychiatric symptoms in VCID by enhancing serotonergic signaling. Preliminary findings in rat models of VCID indicate that expression of serotonin, CGRP, and CFOS in the amygdala is significantly reduced and correlates with anxiety- and depression-like behaviors, suggesting trigeminal nerve stimulation as a potential noninvasive neuromodulatory intervention for addressing the underlying pathophysiology of neuropsychiatric dysfunction in VCID. Performance occurs at The Feinstein Institutes' location in Manhasset, New York. The project runs from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 8/14/26 |