Project Grant R21AG096539
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $868,901 on March 1, 2026, under the Aging Research program (CFDA 93.866) to conduct the Sleep and Circadian Rhythm Biomarkers of Postoperative Neurocognitive Recovery (SLEEP-POD2) study through January 31, 2031. This multisite longitudinal research initiative will enroll 400 older non-cardiac surgery patients (age 65+) from Boston and Baltimore to investigate the relationship between...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $459,250 under the Aging Research program (CFDA 93.866) on June 1, 2025, for a two-year project extending through May 31, 2027. This project grant supports longitudinal research investigating the mechanisms by which stress and resilience influence cognitive aging and Alzheimer's disease (AD) progression. The research will analyze existing data from two natural history,...
- Summary of Federal Project Grant Award The National Institute on Aging awarded $129,330 in Project Grant funding to Massachusetts General Hospital (The General Hospital Corporation) under the Aging Research program (CFDA 93.866) for the period June 15, 2025 through March 31, 2030. This award supports research addressing the critical challenge of early detection and accurate diagnosis of Alzheimer's Disease and Related Dementias (ADRD) through development of a machine learning-based prediction...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a $8.07 million Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, for a five-year project period extending through August 31, 2030. This research initiative examines unique markers and risk factors for Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) in foreign- and native-born older Chinese Americans through an...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $1.58 million Project Grant on March 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's disease. The research initiative, which extends through January 31, 2030, investigates the physiological mechanisms through which the apolipoprotein E-epsilon 4 (APOE-E4) allele—the...
- Federal Grant Award Summary Massachusetts General Hospital (The General Hospital Corporation) received a $3.17 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through February 14, 2030. The award funds development and evaluation of cell therapy approaches to treat Alzheimer's disease by restoring inhibitory neural circuit function. The research focuses on transplanting embryonic mouse medial ganglionic...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a Project Grant of $134,726 on February 18, 2026, under the Aging Research program (CFDA 93.866) to support research investigating the biological mechanisms of proteomic aging and frailty prediction. The project, scheduled for completion by January 31, 2028, will deliver three primary research products: (1) identification of causal aging proteins associated with chronic diseases through...
- Federal Grant Award Summary The National Institute on Aging awarded a $684,567 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) for a four-year research initiative beginning March 1, 2026 and concluding December 31, 2029, under the Aging Research program (CFDA 93.866). The grant supports a resubmission methodology study designed to assess the utility of 64Copper-Fibrin-Binding-Probe-8 Positron Emission Tomography (64Cu-FBP8 PET) for in vivo detection and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a five-year Project Grant totaling $619,099 to the University of California, Irvine, effective February 1, 2026 through January 31, 2031, under the Aging Research program (CFDA 93.866). The research initiative investigates longitudinal relationships between Alzheimer's Disease (AD) pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The project will employ an...
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $487,574 Project Grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the role of reactive astrocytes in the propagation and clearance of tau pathology in Alzheimer's disease. The project, with a completion date of February 28, 2030, will deliver scientific research outputs aimed at understanding whether glial fibrillary acidic...
The National Institute on Aging (NIA) awarded a $453,750 Project Grant to Massachusetts General Hospital (MGH) on February 15, 2026, under the Aging Research program (CFDA 93.866) to establish and conduct a longitudinal cohort study examining sleep, circadian rhythm disruptions, and cognitive outcomes in older Chinese immigrants aged 65 and above. The research will establish a cohort of 100 older Chinese immigrants—referred to as "zeroth generation" immigrants—to investigate how migration stress, acculturation challenges, sleep disorders, and circadian function disruptions impact cognitive performance and aging outcomes in this understudied population. The project leverages MGH's multidisciplinary research team with expertise in sleep science, circadian rhythms, gerontology, immigrant health, and population health research to address critical knowledge gaps regarding the intersection of sleep, circadian biology, and cognitive aging in older immigrant populations who face pronounced cultural adjustment, language barriers, and social isolation. The grant period extends through January 31, 2028, and will be executed through MGH's Research Management Division in Charlestown, Massachusetts. This research aligns with the NIA's mission to support biomedical and behavioral research advancing understanding of aging processes and age-related conditions, with particular emphasis on identifying prevention and treatment approaches for conditions affecting older adults across diverse populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $453.8k | 2/3/26 |