Project Grant R21AG096255
- The National Institute on Aging awarded Wake Forest University Health Sciences $668,290 on February 15, 2026, under the Aging Research program (CFDA 93.866) to decipher the metabolism and protective role of docosahexaenoic acid (DHA), an essential omega-3 nutrient. The project will investigate how the enzyme ACSL6 regulates DHA metabolism in neurons and determine whether DHA protects against neurological disease, particularly alpha-synuclein aggregation associated with synucleinopathy. The...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $170,668 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support research into s-nitrosylated phospholipase D3 in Alzheimer's disease pathophysiology. The funded research investigates the mechanistic role of s-nitrosylated phospholipase D3 (SNO-PLD3) in Alzheimer's disease. The work builds on prior mass spectrometry findings that...
- This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging awarded The Washington University $642,991 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate genetic drivers of phenotypic variability in autosomal dominant Alzheimer's disease using a multi-omics approach. The research identifies genetic alterations associated with Alzheimer's disease risk and presentation in individuals carrying mutations in the PSEN1, APP, and PSEN2 genes. The project characterizes transcriptomic brain profiles...
- The National Institute on Aging, an office of the National Institutes of Health, awarded the University of California, Davis $683,331 under the Aging Research program (CFDA 93.866) on September 1, 2026, to identify and validate causal risk genes and proteins contributing to Alzheimer's disease and its neuropsychiatric symptoms. The research integrates genome-wide association study (GWAS) findings with functional omics data from post-mortem brain tissues to pinpoint proteins mediating Alzheimer's...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $442,750 to the University of California, Davis on September 1, 2026, under the Aging Research program (CFDA 93.866, assistance type: Project Grant) to investigate galectin-12's role in neuroinflammation and Alzheimer's disease progression. The funded research examines how metabolic stress triggers Alzheimer's disease by enhancing inflammation, with a focus on lipid droplet...
- The National Institute on Aging awarded $526,607 to Wake Forest University on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop computational imaging frameworks that integrate neuroimaging with multi-omics data to identify Alzheimer's disease subtypes and model neurodegenerative progression with calibrated uncertainty. The project, titled "Neuroimaging Multi-Omics Fingerprints for Subtyping and Uncertainty-Aware Prediction of Alzheimer's Disease," will...
- The National Institute on Aging awarded the University of Washington $1,212,446 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal analysis of multi-omics biomarkers and their association with cognitive decline and dementia. The recipient will leverage serial multi-omics data with deep phenotyping to map mechanisms of cognitive decline and dementia and nominate druggable targets. The work uses two discovery and replication cohorts: the Cardiovascular...
- The National Institute on Aging awarded Rensselaer Polytechnic Institute $698,712 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate apolipoprotein E and reelin interactions in Alzheimer's disease pathology. The research tests the hypothesis that APOE E4 competes with reelin for receptor and heparan sulfate binding, thereby reducing protective reelin signaling and increasing Alzheimer's disease risk. Work includes mechanistic studies using split luciferase assays...
The National Institute on Aging awarded the Fatty Acid Research Institute $412,500 on September 1, 2026, under the Aging Research program (CFDA 93.866) to establish interaction polygenic risk scores for blood omega-3 fatty acids and genetic variants as predictors of incident all-cause dementia and Alzheimer's disease. The research identifies genetic variants that interact with blood docosahexaenoic acid (DHA) levels as risk factors for Alzheimer's disease and related dementias, with the goal of determining which individuals, based on genetic profile, will most benefit from increased dietary DHA intake. The project addresses heterogeneity in epidemiological evidence on DHA's protective effects by examining how genetic background modifies the relationship between blood DHA levels and dementia risk, hypothesizing that genetic variants beyond APOE-E4 interact with DHA as predictors of cognitive decline. The award period runs from September 1, 2026, through August 31, 2028. Work is performed in Sioux Falls, South Dakota. The Aging Research program supports biomedical, social, and behavioral research and training directed toward understanding aging processes and diseases affecting older adults, with particular emphasis on Alzheimer's disease prevention and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $412.5k | 9/1/26 |