Project Grant R21AG093754
- Federal Project Grant Award Summary The University of Michigan's Regents received a $442,695 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded May 1, 2025, with completion targeted for January 31, 2027. This proof-of-concept research initiative aims to develop immunocytokines—monoclonal antibodies (MAbs) or bispecific antibodies (BAbsbs) fused to macrophage colony-stimulating factor (M-CSF)—to achieve selective, sustained, and localized...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Michigan a $422,319 Project Grant effective September 15, 2025, through September 14, 2027, under the Aging Research program (CFDA 93.866). The award supports the development and feasibility testing of the Community Care Transition Initiative-Alzheimer's Disease and Related Dementias (CCTI-ADRD), an adapted pharmacist-led care transition program designed for rural older adults with dementia and their care...
- Federal Grant Award Summary The University of Michigan's Regents, Office of Research and Sponsored Projects, received a $1.73 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct comprehensive research on genetic determinants of cognitive outcomes under caloric restriction. The award, obligated on March 1, 2026, with completion anticipated by January 31, 2031, supports the first systems genetics analysis using the Diversity...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan a $303,449 project grant effective June 1, 2025, through May 31, 2027, under the Aging Research program (CFDA 93.866) to investigate the genomic impact of transposable elements (TEs) in Alzheimer's disease and related dementias (ADRD). The research will leverage large-scale genomic datasets and clinical information from major Alzheimer's disease cohorts to overcome analytical challenges...
- Federal Project Grant Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $655,198 project grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective March 1, 2026, through November 30, 2030. This award supports research focused on developing non-invasive methods for modulating microglia gene expression through peripherally administered antibody conjugates. The project addresses a significant gap in current...
- Federal Grant Award Summary The University of Florida Division of Sponsored Research received a $2.33 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2029. This award supports a four-year research initiative investigating the neuroimmune mechanisms of the luteinizing hormone/choriogonadotropin (LH/CG) receptor as a therapeutic target for cognitive decline associated with menopause and...
- Federal Grant Award Summary The University of Michigan received a $10.4 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on August 1, 2025, with completion scheduled for July 31, 2029. This research initiative represents the first study evaluating personalized brain stimulation as a treatment for Posterior Cortical Atrophy (PCA), a neurodegenerative condition most commonly caused by Alzheimer's disease. The primary deliverable...
- Federal Grant Award Summary The University of Southern California received a $4.06 million Project Grant from the National Institute on Aging (part of the National Institutes of Health) under the Aging Research program (CFDA 93.866), awarded on September 15, 2025, with completion scheduled for August 31, 2029. This research project will investigate the impact of circulating levels of endocrine disrupting persistent organic pollutants on cognition, brain activity, and Alzheimer's disease (AD)...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $148,050 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 27, 2025, with a completion date of May 31, 2028. The award funds research investigating sex-specific hypothalamic pathology and immune infiltration in Alzheimer's disease (AD), addressing the documented disparity that nearly two-thirds of AD cases occur in females. The...
- Federal Project Grant Award Summary The University of Michigan's Regents received a $2,991,725 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports fundamental biomedical research investigating how reactive oxygen species (ROS) and early-in-life oxidative stress modulate lifespan and aging processes. The research employs a multipronged approach utilizing model...
The National Institute on Aging awarded $424,371 to the Regents of the University of Michigan on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a two-year research project examining how hormone contraceptive (HC) exposure throughout a woman's lifetime protects against Alzheimer's disease progression. The research will deliver scientific insights into the mechanisms by which cumulative lifetime estrogen exposure and progestin-modulation of stress-related signaling reduce cognitive decline and dementia risk in women, who develop Alzheimer's disease at twice the rate of men. This project directly addresses a critical national health priority identified by the National Institute on Aging to advance understanding of prevention and treatment strategies for Alzheimer's disease and related dementias. The University of Michigan will employ preclinical research methodologies utilizing a mouse model of hormonal contraceptive exposure combined with the APP/PS1 Alzheimer's disease model, supplemented by behavioral, pharmacological, and molecular analytical tools to evaluate protective mechanisms. Deliverables will include research findings on how hormone contraceptive exposure mitigates stress-induced cognitive impairment, amyloid-beta accumulation, and neuroimmune activation in brain regions critical to memory and cognition. The research outcomes are expected to provide evidence-based understanding of modifiable risk factors for Alzheimer's disease and may inform public health approaches to dementia prevention in aging populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $424.4k | 2/6/26 |