Project Grant R21AG093333

Award Date 5/15/25
Completion Date 4/30/27
Dollars Obligated $461K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01655, USA
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The key research objectives are to: 1) Determine how influenza virus and aging impact MLKL-mediated platelet content release and whether platelets undergo necroptosis, and 2) Assess the contribution of aging to MLKL activation and immunothrombotic aggregates during infection. This research aims to elucidate mechanisms that may increase the risk of immunothrombotic complications and adverse cardiovascular outcomes in older adults with viral respiratory infections, providing a foundation for novel treatments. The award period is from May 15, 2025 to April 30, 2027.

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