Project Grant R21AG093316
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $448,961 to Telohealthdx LLC to develop a low-cost, accurate, and high-throughput DNA array and fluorescent in situ hybridization (FISH)-based method to measure the absolute lengths of individual telomeres. The goal is to create an improved diagnostic test for telomere-associated diseases, which are prevalent among the aging population and include conditions like dyskeratosis congenita, aplastic...
- This $430,101 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and genetic variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, explore the phenome-wide consequences of telomere length using large-scale biobank data, and identify...
- The National Institute on Aging (NIA) awarded a $430,956 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Duke University. The grant aims to (1) identify novel clinical and 'omic risk factors, including telomere length, mitochondrial copy number, and clonal hematopoiesis, for organ dysfunction and early mortality in sickle cell disease (SCD), and (2) identify proteomic and glycoproteomic biomarkers for premature mortality in SCD. The research seeks to elucidate the...
- This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research provides $133,353 to Mayo Clinic to investigate the molecular mechanisms of T cell-mediated surveillance of senescent cells under both physiological and aging conditions. The research aims to define how senescent cells deploy their secretome to sensitize human T cells, assess co-stimulatory and co-inhibitory interactions between senescent cells and T cells, and perform translational studies...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $320,511 project grant to TRU Diagnostics Inc. to develop a novel diagnostic tool for chronic diseases. The project aims to create a "non-stochastic W function epigenomic roadmap" using systems-based dynamic modeling to capture the shifting homeostatic set points of epigenetic markers over time. This transformative approach aims to enable personalized, dynamic health forecasts...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
- This federal Project Grant award of $150,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The grant supports research by Mayo Clinic to study the clinical significance of somatic mosaic states in the context of short telomeres, which are associated with Telomere Biology Disorders (TBD). Specifically, the research aims to create and characterize a new...
- This federal Project Grant award in the amount of $124,875.00 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to Cedars-Sinai Medical Center. The grant supports research by Dr. Larissa Langhi Prata, an Assistant Professor at the Kogod Center on Aging at Mayo Clinic, to investigate the role of senescent cells in the susceptibility of elderly and chronically ill patients to infectious diseases. The research aims to provide insights into the biology of aging and its...
- This federal Project Grant award of $424,565.00, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports advanced biomedical research at the Mayo Clinic in Rochester, Minnesota. The research aims to investigate the clinical significance of somatic genetic variants in telomere biology disorders. This grant, with a performance period from September 1, 2025 to August 31, 2028, contributes to the Defense Health Agency's broader...
- This federal Project Grant award of $413,385 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the structure-function relationship between the TPP1 protein and telomere length control. The award supports comprehensive experiments using deep scanning mutagenesis of TPP1 to characterize the effects of mutations on telomere length, with the goal of identifying mutations that drive changes in telomere length. The research also seeks to uncover the molecular...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $441,100 Project Grant to the Mayo Clinic to conduct a multiomic analysis of the downstream molecular effects of telomere length in individual chromosome arms of healthy human cells. The research aims to test the hypothesis that individual chromosome arm-specific telomere lengths are clinically relevant in the diagnosis and understanding of telomere biology disorders, and that shortened telomeres can trigger transcriptomic and epigenomic changes involved in the pathogenesis of these diseases. The project will leverage the Mayo Clinic's existing patient cohort and expertise in telomere biology research to develop novel bioinformatics approaches for accurately measuring individual telomere lengths and investigating their connection to gene expression patterns. This award supports the Mayo Clinic's ongoing efforts to advance scientific understanding of the aging process and age-related health conditions through innovative, multidisciplinary research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.1k | 7/29/25 |