This Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) provides $1,489,256 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the effects of a ketogenic diet on brain energy metabolism in aging and Alzheimer's disease. The key products and services to be delivered under this award include: 1) Developing advanced magnetic resonance spectroscopy techniques to measure biomarkers of brain energy metabolism, including...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
This $2,010,291 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to The Johns Hopkins University. The grant aims to leverage whole-genome sequencing, metabolomics, and proteomics data to identify novel biomarkers and causal relationships between mitochondrial function and aging-related diseases, including all-cause mortality, cardiovascular disease, and frailty. The research will first identify plasma metabolites...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets; 2)...
This Project Grant award, funded by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, is providing $239,338 to the University of Alabama at Birmingham (UAB) to investigate the role of tRNA-derived short and long RNAs in the aging process. The project aims to determine if these RNA species contribute to lifespan or proteostasis changes associated with aging, through studies in the yeast model organism. Key aspects include overexpressing or depleting the...
This National Institute on Aging (NIA) Project Grant award to Emory University, under the Aging Research program (CFDA 93.866), provides $430,375 to determine whether the microbiome metabolite valerobetaine (VB) promotes a mitochondrial aging phenotype in old mice and to test whether VB antagonizes the beneficial effects of carnitine (acetylcarnitine) on mitochondrial aging. The two-year project, running from September 2023 to September 2025, will conduct experimental studies in young and old...
The Scintillon Institute, a non-profit biomedical research organization, received a $529,650 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated bypass of the mitochondrial electron transport chain. The research aims to identify endogenous metabolites interconverted by NQO1 and characterize the bioenergetics of this alternative electron transfer mechanism, with the goal of developing therapeutic...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...
This Project Grant award of $3,772,856.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The purpose of the award is to investigate how disruptions in glycolysis, a key energy metabolism process, contribute to neurodegeneration in rodent models of Alzheimer's disease (AD). The research will interrogate glycolysis in tau and amyloid mouse models of AD, measuring metabolomics, cognitive function, PET imaging, and protein...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $123,309 to The Regents of the University of California, San Francisco (UCSF) to investigate the role of fatty acid signaling in regulating the translatome during fasting and aging. The research aims to identify the molecular mechanisms underlying fatty acid-induced translation control, including the functional cis-regulatory motifs in mRNAs and the upstream signals induced by fatty acids....