This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
This Project Grant award, identified as F30AG085921, was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $322,924 award aims to investigate the behavioral and neural drivers of pain resilience in older adults with chronic musculoskeletal pain. The study will leverage data from the Health, Aging and Body Composition Study, a longitudinal cohort of over 3,000 older adults, to examine how neural and behavioral measures of...
This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing and optimizing novel small-molecule probes targeting nicotinic acetylcholine receptors containing the alpha-9 subunit (α9*-nAChR) for pain management. The $650,079 in funding will support a 5-year research project at Northeastern University to advance the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $970,052 to Backstop Neural, Inc. to demonstrate the feasibility of a novel paddle-type epidural stimulation lead to relieve chronic arm and neck pain. The key objectives are to: 1) Design and fabricate a 16-channel, 0.2 mm thick human-sized softening paddle lead; 2) Demonstrate the mechanical and electrical stability of the...
This federal Project Grant award, totaling $1,612,516.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, awarded on August 1, 2024, supports research at the University of Illinois focused on investigating the role of nicotinic acetylcholine receptors in neuropathic pain. The project aims to advance scientific understanding of the neural...
This Project Grant award of $597,999.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will fund research focused on understanding the neuronal populations and central sensitization mechanisms that underlie mechanical allodynia, a condition where normally innocuous touch or movement becomes painful after an injury. The research...
This federal Project Grant award, valued at $238,276, was provided by the National Institute of Neurological Disorders and Stroke under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The funding supports research at the University of California, Irvine to investigate the role of the enzyme N-acylethanolamine acid amidase (NAAA) in the development of hyperalgesic priming, a model for studying the transition from acute to chronic pain. The project aims to identify the receptor...
This $408,000 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research to provide a comprehensive EEG profile of the cortical activity underlying the cognitive processing of the sensory-discriminative and affective-motivational dimensions of osteoarthritis knee pain. The research, conducted by Tarleton State University,...