Project Grant R21AG086857

Award Date 9/1/24
Completion Date 5/31/26
Dollars Obligated $427K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Roanoke, VA 24016, USA
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This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $10,847,672 to the J. David Gladstone Institutes, a non-profit biomedical research organization, to investigate the vascular-immune mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease pathology. The research aims to elucidate the key microglial mechanisms regulating the formation of vascular CAA versus parenchymal amyloid-beta plaques, define single-cell and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $416,480 to the University of Washington to map the landscape of the aged human brain and develop neurodegenerative disease models. The award will fund a two-phase research project that aims to: 1) identify molecular drivers of brain aging by applying explainable artificial intelligence (XAI) methods to human brain datasets, and 2) manipulate these aging drivers in human induced pluripotent stem...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to conduct research on the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The 5-year project aims to leverage experimental mouse models, molecular characterization of endogenous retroviruses, and human induced pluripotent stem cell models to investigate...
This Project Grant award of $2,683,965 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support the development and optimization of an improved all-human cellular system, or "brain-chip", for studying Alzheimer's disease and related dementias (ADRDs). The key objectives are to: 1) define delivery conditions for introducing patient blood cells and plasma into...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the role of microglia, the brain's immune cells, in the development of Alzheimer's disease (AD). The University of Washington (UW) will leverage novel explainable AI techniques and human induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes that occur early in AD progression. Specifically, UW will expose microglia-neuron iPSC cultures to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
The National Institute on Aging awarded a $1,931,965 Project Grant (CFDA 93.866 - Aging Research) to the Regenerative Research Foundation, a non-profit organization in Albany, New York. The purpose of this federal grant is to develop and validate a novel human induced pluripotent stem cell (iPSC) model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, and microglia to study cerebrovascular interactions in Alzheimer's disease-related dementias (ADRD). The R61 phase of...

This Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) will provide $426,829 to Virginia Polytechnic Institute & State University from September 1, 2024 to May 31, 2026 to develop a microphysiological system that models the brain-meninges-lymph node axis in both healthy conditions and Alzheimer's disease. The goal is to create a modular, all-human system that can be used to study the interactions between the brain, meninges, and lymph nodes, and the impact of Alzheimer's disease on these components. The project will integrate tissue-engineered models of the human brain, lymph node, and meninges into a microfluidic device to enable fluid flow, drug testing, and disease modeling. A sub-award of unspecified amount will be provided to the University of Virginia to contribute to this research.

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