This $513,957 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to understand the role of lymphatic endothelial cell NF-kB signaling in the maintenance of adult lymph nodes. The two-year study, running from September 2024 to August 2026, will be conducted by the Sloan-Kettering Institute for Cancer Research. Key research activities include single-cell RNA sequencing analysis of lymph node stromal cells, as well as the use of inducible transgenic mouse...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This federal Project Grant award for $351,750 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to Yale University. The award will fund a 5-year research project to investigate the role of the protein NLRX1 in regulating immune system changes associated with aging. The primary goal is to elucidate the mechanisms by which decreases in NLRX1 levels contribute to age-related alterations in T cell function, including memory T cell expansion, reduced...
This $428,397 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 3-year research study at the University of Pikeville to investigate thymic aging in the elderly human population. The study aims to qualitatively and quantitatively assess the structure and function of the thymus, a primary lymphatic organ, in cadavers of elderly individuals to determine the degree of thymic involution and identify stages of preserved thymic activity. The research...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The study aims to investigate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence. Specific objectives include re-evaluating the Hayflick limit, assessing...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $418,000.00 is aimed at elucidating the role of B cells and antibodies in the pathophysiology of aging and associated neurodegeneration. The key objectives are to analyze the immunoglobulin repertoire and phenotype of B cells present in cerebral spinal fluid (CSF) versus peripheral blood in young and elderly individuals. This work will determine the extent to which peripheral B...
This Project Grant award of $158,918 from the National Institute on Aging (CFDA 93.866 Aging Research) will support Vanderbilt University's research into the effects of lifestyle on immune function and molecular aging across different populations. The study will use a multi-omic approach to characterize age-related changes in gene expression, DNA methylation, and clonal hematopoiesis in subsistence-level groups like the Tsimane, Turkana, and Orang Asli, as well as urban populations in the U.S....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $525,716 to the Fred Hutchinson Cancer Center in Seattle, WA to investigate the mechanisms of aging in the genetic model organism C. elegans. The research aims to study the origin and role of intranuclear lamin and lipid droplets in the deterioration of intestinal cells during aging. The project uses forward and reverse genetics approaches in C. elegans to identify pathways that contribute to or...
This federal Project Grant award of $2,980,142 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop an ex vivo "aged B cell follicle" organoid technology. The goal is to create a tissue-engineered model of aged lymphoid tissues that can induce early germinal center (GC) programming of aged B cells from mice and humans. This will enable the study of plasma cell fate and...