Project Grant R21AG085288

Award Date 9/1/24
Completion Date 6/30/26
Dollars Obligated $435K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, NY 10031, USA
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This federal Project Grant award, with identification number R21AG085288, was provided by the National Institute on Aging under the Aging Research grant program (CFDA 93.866). The $434,500 award, with a period of performance from September 1, 2024 to June 30, 2026, will support research into the dopaminergic mechanism underlying familiarity bias and memory interference in aging.

The key objectives of this project are to investigate how dysfunction in dopamine neurons projecting to the lateral entorhinal cortex (LEC) affects memory interference in older mice. The research will use fiber photometry and optogenetic manipulations to measure dopamine transients in the LEC and determine the role of dopamine in promoting familiarity processing. Additionally, the project will assess the impact of dopamine neurons on reactivating neuronal representations of familiar memories in the LEC. This research aims to elucidate the LEC microcircuits involved in proactive memory interference and lay the foundation for further inquiry into age-related biases towards familiarity.

The award was granted to the Research Foundation of the City University of New York, which will serve as the primary awardee for this project.

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