Project Grant R21AG085061
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $705,385 to Northeastern University to conduct a large-scale study investigating mediators and moderators of executive function training in older adults. The study aims to improve the rigor and reproducibility of research on cognitive plasticity in older adults, many of whom are at risk for Alzheimer's disease and related dementias. The study will collect data from 1,250 older adults aged 60+ to...
- This $375,840 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of advanced machine learning models to enable accurate and early prediction of Alzheimer's disease and related dementias (ADRD). The project, led by the University of Virginia, will leverage novel natural language processing techniques to automatically extract personal risk factors for ADRD from electronic health...
- This $1,012,879 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University (NYU) to develop three novel statistical machine learning methods for Alzheimer's disease (AD) research using multi-view imaging, genomic, and clinical data. The specific aims include: 1) developing a multi-view data decomposition method to construct brain and genomic networks across AD statuses, 2) developing an optimal false discovery rate control method to...
- This federal Project Grant award of $441,612 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University (Boston University Medical Campus) supports research to evaluate the use of digital cognitive measures, such as digital pen tasks and voice recordings, to monitor early cognitive decline in relation to modifiable Alzheimer's disease risk factors. The project aims to leverage the Framingham Heart Study's longitudinal data on digital cognitive...
- This Project Grant award of $640,067 from the National Institute on Aging (CFDA 93.866 Aging Research) will fund the development of novel multimodal variational autoencoder (VAE) models to learn factors associated with cognitive resilience to Alzheimer's disease (AD) and related dementias. The University of Michigan, the awardee, will employ generative methods to discover new factors from existing multimodal data (molecular, anatomic, functional imaging, cognitive) and model dynamic...
- This federal Project Grant award of $495,731.00, awarded on September 20, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports the evaluation of Viewmind's ability to detect beta-amyloid and tau burden consistent with Alzheimer's disease in persons with mild cognitive impairment (MCI) using machine learning, virtual reality, and eye-tracking technology. The project aims to develop a non-invasive, cost-effective, and rapid diagnostic tool that can accurately...
- This federal Project Grant award of $150,000.00, funded by the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CISE) program (CFDA 47.070), aims to develop advanced machine learning models and algorithms for the early prediction of Alzheimer's Disease and Related Dementias (ADRD) using electronic health record (EHR) data. The research project, led by the University of Iowa, will leverage natural language processing techniques to automatically extract...
- This federal Project Grant award of $327,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to leverage multimodal data, including traditional neuropsychological tests and digital voice recordings, to identify preclinical cognitive trajectories related to Alzheimer's disease. The project, titled "Exploring Heterogeneity of Cognitive Trajectories of Preclinical Alzheimer's Disease with Digital Phenotyping," will build a comprehensive model of cognitive...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $499,686 to support the development of the Momento smartphone app. The app aims to transform regular photo activities into a way to continuously monitor cognitive function and detect early signs of memory changes in older adults. Key goals of the 1-year project include: 1) Testing how 200 older adults use and enjoy the app, ensuring it is engaging for regular use; and 2) Verifying the system can...
This $440,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the development and validation of natural language processing tools for automated scoring of autobiographical memory interviews. The project aims to: Use advanced machine learning methods to improve the accuracy of the AI-powered memory scoring software, which has already shown strong agreement with manual scoring in preliminary validation. This will be achieved by fine-tuning large language models using a large dataset of annotated memory details. Develop new software capabilities to score memories across nine categories of episodic and non-episodic information, including spatial and perceptual details. Conduct extensive psychometric analyses to evaluate the validity and reliability of the automated memory scoring software. The award recipient is Northeastern University, a private research university known for its expertise in AI, cybersecurity, and advanced engineering solutions. This project leverages Northeastern's capabilities to enable larger-scale longitudinal studies on autobiographical memory decline in Alzheimer's and other memory disorders, which is critical for developing effective treatments and interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 8/20/25 |