The National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) Federal Grant Program, awarded a $440,000 Project Grant to Northwestern University to test the hypothesis that nasally exhaled breath contains biomarkers for Alzheimer's disease (AD). The 2-year grant, awarded on December 15, 2024, aims to quantify AD biomarkers (tau and beta-amyloid proteins) in nasally and orally exhaled breath samples from patients with AD, age-matched healthy controls, and healthy young adults....
The National Institute on Aging (NIA) awarded a $446,619 Project Grant (CFDA 93.866 - Aging Research) to the University of North Carolina at Chapel Hill to develop and evaluate an olfactory-based approach for measuring memory function and cognitive aging in diverse global populations. The project aims to rigorously assess the Percepts of Odor Episodic Memory (POEM) protocol, which measures olfactory memory as a predictor of Alzheimer's disease and related dementias. The research will be...
This Project Grant award of $5,554,915, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to investigate the role of epigenetics, specifically DNA methylation, in understanding the pathogenesis of post-operative delirium (POD) and its relationship with long-term cognitive decline among elderly patients with dementia. The primary objective is to identify potential biomarkers associated with the elevated risk of POD and subsequent patient...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,500.00 to investigate the role of perineuronal nets (PNN) in the development of postoperative delirium in aged mice. The research aims to test the hypothesis that changes in PNN and parvalbumin-positive neurons coincide with delirium-like cognitive impairment in aged mice subjected to anesthesia, surgery, and intensive care unit (ICU)-like conditions. The project will also examine whether...
This Federal Project Grant award of $154,748 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop an ultrasensitive blood-based diagnostic tool for Alzheimer's disease (AD). The grant recipient, Brigham & Women's Hospital Inc., will work closely with Dr. David Walt at the Wyss Institute to create a pipeline for efficiently isolating extracellular vesicles (EVs) from plasma and quantitatively assessing the phosphorylation state of AD biomarkers using Single...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $382,645 to the Rector & Visitors of the University of Virginia (UVA) to support research on identifying individuals with Alzheimer's disease and related dementias (ADRD) who are at high risk for developing epilepsy. The award recipient, Dr. Ifrah Zawar, will develop and test a risk stratification algorithm to predict epilepsy in individuals with ADRD, and assess the feasibility of using...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $558,930.00 to the University of Virginia to conduct an intensive longitudinal assessment of human olfaction (i.e., smell). The study aims to document typical olfactory fluctuations in healthy adults, changes in olfactory function associated with the menstrual cycle or pregnancy, and...
The National Institute on Aging (NIA), under the Federal Aging Research program (CFDA 93.866), awarded a $245,148 project grant to Eyenexo LLC to develop an automated rodent behavior testing system for non-invasively assessing early-stage Alzheimer's disease (AD). The project aims to develop a behavior biomarker that can differentiate AD from normal aging by studying defensive behaviors triggered by looming stimuli, which are linked to early AD pathology in the midbrain region. The 2-year...
The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
The National Institute on Aging (NIA), under the federal Aging Research grant program (CFDA 93.866), awarded a $1,703,626 Project Grant to the University of North Dakota (UND) Division of Research & Economic Development. The grant, effective September 1, 2023 through August 31, 2026, will fund research to investigate the potential link between lung dysfunction and the progression of Alzheimer's disease (AD). Key objectives include: Characterizing the temporal changes in AD-related lung...