Project Grant R21AG083558

Award Date 9/1/23
Completion Date 8/31/25
Dollars Obligated $380K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Phoenix, AZ 85012, USA
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This Project Grant award for $380,060 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research by the Arizona Veterans Research And Education Foundation, a non-profit organization, to evaluate anti-Medin immunotherapy for addressing vascular aging and related dementias.

The project aims to develop and test the efficacy of an anti-Medin vaccine (Aim 1) as well as anti-Medin monoclonal antibodies (Aim 2) in preventing or attenuating cerebrovascular dysfunction, cognitive impairment, and neurovascular pathology in aged mice and a senescence-accelerated mouse model. The research involves studies on the role of Medin, an amyloidogenic peptide associated with vascular disease, in driving endothelial dysfunction and neuroinflammation. Successful outcomes could establish Medin as a new therapeutic target for vascular aging and dementia.

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