Project Grant R21AA033945
- The National Institute on Alcohol Abuse and Alcoholism awarded Loyola University of Chicago Health Sciences Campus $470,066 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct basic research on the molecular mechanisms by which ABL kinase 2 (ABL2) contributes to alcohol-associated liver disease pathogenesis. The research will investigate three specific areas: the molecular mechanisms by which ABL2 promotes alcohol-induced steatosis; the role of ABL kinases in...
- The National Institute on Alcohol Abuse and Alcoholism awarded Public Health Institute $1,291,065 under the Alcohol Research Programs (CFDA 93.273) on September 20, 2025. The project conducts analyses of alcohol-related mortality in the United States with emphasis on spirits consumption, examining mortality rate relationships with beverage-specific per capita consumption and policy interventions. The work addresses mortality trends that have increased dramatically since 1999 and particularly...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Illinois $110,228 on November 10, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct time-resolved, single-nucleus multiomics research on HMGB1-mediated mechanisms of alcohol-associated liver disease progression and recovery. The project will deconvolute bulk RNA-sequencing datasets from human alcohol-associated liver disease samples using human single-cell RNA-sequencing references to quantify...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical College of Wisconsin, Inc., $248,959 on September 12, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a five-year longitudinal study examining reciprocal associations between brain function and alcohol use trajectories in adolescents and young adults. The recipient will assess prospective long-term associations between reward processing, cognitive control, and alcohol use patterns using two large...
- The National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health within the Department of Health and Human Services, awarded $682,736 to Beth Israel Deaconess Medical Center, Inc. on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate myeloid-derived suppressor cells (MDSCs) in alcohol-associated steatohepatitis. The award funds research characterizing MDSC phenotypes and immunoregulatory capacity in alcohol-associated hepatitis...
- The National Institute on Alcohol Abuse and Alcoholism awarded Beth Israel Deaconess Medical Center, Inc. $177,736 on August 17, 2026, under the Alcohol Research Programs (CFDA 93.273) to support a postdoctoral researcher's career development in understanding the role of neutrophil extracellular traps (NETs) in alcohol-induced acute-on-chronic liver failure. The award funds a two-year mentored research program spanning August 17, 2026, through July 31, 2028, based in Boston, Massachusetts. The...
- The National Institute on Alcohol Abuse and Alcoholism awarded Beth Israel Deaconess Medical Center, Inc. $2,072,751 under the Alcohol Research Programs (CFDA 93.273) on September 15, 2025. The recipient is conducting research into innate immune dysregulation in alcohol-associated liver disease, with focus on neutrophil heterogeneity and dysfunction in alcohol-associated hepatitis. The work characterizes transcriptomic profiles and functional roles of neutrophil populations—specifically...
- The National Institute on Alcohol Abuse and Alcoholism, part of the Department of Health and Human Services National Institutes of Health, awarded Mayo Clinic $404,352 on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop machine learning and spatial transcriptomics tools for diagnosis and prognosis of alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), and mixed-etiology metabolic syndrome-associated alcoholic...
- The National Institute on Alcohol Abuse and Alcoholism awarded Loyola University of Chicago Health Sciences Campus $494,424 on September 16, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate RNA splicing regulation during alcohol withdrawal. The research, led by Dr. Luana Carvalho, examines how chronic alcohol exposure alters gene expression and RNA splicing in the brain, with a focus on the splicing factor PCBP1 (poly R(C) binding protein). The project investigates...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Washington University $555,331 on August 13, 2026, under the Alcohol Research Programs (CFDA 93.273) to examine the metabolic-epigenetic regulation of alcohol intake and associated molecular mechanisms. The funded research explores how alcohol-derived acetate generated during alcohol metabolism affects brain histone acetylation and subsequently influences alcohol intake behavior. The project builds on preliminary findings...
The National Institute on Alcohol Abuse and Alcoholism awarded Loyola University of Chicago Health Sciences Campus $115,500 on August 17, 2026, under the Alcohol Research Programs (CFDA 93.273) to identify leading causes and pathways of death in alcoholic acute respiratory distress syndrome (ARDS) patients through computational analysis of clinical trial datasets. The recipient will conduct a retrospective cohort study validating findings across five NIH-funded, multicenter, randomized, double-blinded clinical trials enrolling 5,568 ARDS patients. The work applies machine learning and causal inference methods to rank leading predictors of mortality by combining random forest and SHAP algorithms, comparing outcomes between patients with and without alcohol misuse. Using reliable causal inference approaches, the study analyzes 1,204 clinical variables to identify causal pathways specific to alcohol misuse in ARDS populations, building on a prior pilot study of 1,149 patients across three ARDSNet trials. The period of performance runs through July 31, 2028, with work performed at the Health Sciences Campus in Maywood, Illinois. This is a Project Grant assistance type under the federal program supporting research to develop improved treatment methods and prevention strategies for alcoholism and alcohol-related medical disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $115.5k | 8/19/26 |